Now showing items 1-20 of 454

    • 3-Chloro-N′-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy 

      Sarno, Federica; Papulino, Chiara; Franci, Gianluigi; Andersen, Jeanette hammer; Cautain, Bastien; Melardo, Colombina; Altucci, Lucia; Nebbioso, Angela; Andersen, Jeanette H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-07)
      Despite the discovery and development of novel therapies, cancer is still a leading cause of death worldwide. In order to grow, tumor cells require large quantities of nutrients involved in metabolic processes, and an increase in iron levels is known to contribute to cancer proliferation. Iron plays an important role in the active site of a number of proteins involved in energy metabolism, DNA ...
    • Adjuvant activity of fish type I interferon shown in a virus DNA vaccination model 

      Chang, Chia Jung; Sun, Baojian; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-09)
      There is a need for more efficient vaccines to combat viral diseases of Atlantic salmon and other farmed fish. DNA vaccines are highly effective against salmonid rhabdoviruses, but have shown less effect against other viruses. In the present work we have studied if type I IFNs might be used as adjuvants in fish DNA vaccines. For this purpose we chose a DNA vaccine model based on the hemagglutin ...
    • Adjuvants and immunostimulants in fish vaccines: Current knowledge and future perspectives. 

      Tafalla, C; Bøgwald, Jarl; Dalmo, Roy Ambli (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Vaccination is the most adequate method to control infectious diseases that threaten the aquaculture industry worldwide. Unfortunately, vaccines are usually not able to confer protection on their own; especially those vaccines based on recombinant antigens or inactivated pathogens. Therefore, the use of adjuvants or immunostimulants is often necessary to increase the vaccine efficacy. Traditional ...
    • Advancing research for the management of long-lived species: A case study on the Greenland Shark 

      Edwards, Jena E.; Hiltz, Elizabeth; Broell, Franziska; Bushnell, Peter G.; Campana, Steven E.; Christiansen, Jørgen Schou; Devine, Brynn M.; Gallant, Jeffrey J.; Hedges, Kevin J.; MacNeil, M. Aaron; McMeans, Bailey C.; Nielsen, Julius; Præbel, Kim; Skomal, Gregory B.; Steffensen, John Fleng; Walter, Ryan P.; Watanabe, Yuuki Y.; VanderZwaag, David L.; Hussey, Nigel E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-02)
      Long-lived species share life history traits such as slow growth, late maturity, and low fecundity, which lead to slow recovery rates and increase a population’s vulnerability to disturbance. The Greenland shark (Somniosus microcephalus) has recently been recognized as the world’s longest-lived vertebrate, but many questions regarding its biology, physiology, and ecology remain unanswered. Here we ...
    • Advection-diffusion models of spiny lobster Palinurus gilchristi migrations for use in spatial fisheries management 

      Santos, Jorge; Rouillard, Denis; Groeneveld, Johan C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-02-17)
    • Aldri mer 18. april! 

      Finstad, Bjørn-Petter; Holm, Petter (Chronicle; Kronikk, 2013-04-18)
      Den 18. april 1989 er et viktig vendepunkt i norsk fiskerihistorie. Det var den dagen Fiskeridepartementet stoppet kystflåtens fiske etter torsk nord for 62. breddegrad - midt i den tradisjonelle sesongen. Reaksjonene lot ikke vente på seg. Historiens første totalforbud mot å fiske torsk var “et sjokk til dyp ettertanke”, het det i Fiskeribladet.
    • Allochrony as a potential driver for reproductive isolation in adaptive radiations of European whitefish ecomorphs 

      Bitz-Thorsen, Julie; Häkli, Katja; Bhat, Shripathi; Præbel, Kim (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-29)
      In northern Fennoscandian lakes, monophylogenetic lineages of postglacial fishes are radiating into several adaptive forms, but the speciation process is still at an incipient stage. The speciation process has received increased attention over the years, but the underlying mechanisms and drivers are still debated and poorly understood. European whitefish (<i>Coregonus lavaretus</i> [L.]) is the most ...
    • Alt på land 

      Svorken, Marianne; Høgstad, Maria Alfredsen; Esaiassen, Margrethe; Nøstvold, Bjørg Helen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-31)
      Mye av restråstoffet som oppstår om bord på norske torsketrålere blir ikke ført til land. I denne artik-kelen drøfter vi hvorfor fartøy i akkurat denne gruppen ikke utnytter restråstoffet bedre. Gjennom en kvalitativ tilnærming supplert med tallanalyser fra landingsstatistikken diskuteres mulige forklarings-variabler og løsninger. Våre resultater viser at ivaretakelse av restråstoff forbindes med ...
    • Alternative bait trials in the Barents Sea snow crab fishery 

      Araya-Schmidt, Tomas; Olsen, Leonore; Rindahl, Lasse; Larsen, Roger B.; Winger, Paul D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-13)
      Commercial harvesting of snow crab (<i>Chionoecetes opilio</i>) in the Barents Sea started in 2012 by Norwegian fishing vessels. This new fishery has significant bait requirements, representing an emerging conservation challenge. In this study, we evaluate the performance of five alternative (natural) baits manufactured from the waste stream of existing and sustainably managed harp seal (<i>Pagophilus ...
    • Analysis of bacterial diversity in the intestine of grass carp (Ctenopharyngodon idellus) based on 16S rDNA gene sequences 

      Han, A; Ringø, Einar; Liu, Yuchan; Zhou, Zhigang; He, Suxu; Cao, Yanan; Bin, Yao (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
    • Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN 

      Robertsen, Børre; Greiner-Tollersrud, Linn; Jørgensen, Lars Gaute (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-06)
      Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. Analysis of the Atlantic salmon genome revealed the presence of 9 Mx genes localized to three chromosomes. A cluster of three Mx genes (SsaMx1 – SsaMx3), which includes previously cloned Mx genes, is present on chromosome (Chr) 12. A cluster of five Mx genes (SsaMx4-SsaMx8) is present on Chr25 while one Mx gene ...
    • “And if you gaze long into an abyss, the abyss gazes also into thee ”: four morphs of Arctic charr adapting to a depth gradient in Lake Tinnsjøen 

      Østbye, Kjartan; Hassve, Marius Hagen; Tamayo, Ana-Maria Peris; Hagenlund, Mari; Vogler, Thomas; Præbel, Kim (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)
      The origin of species is a central topic in biology. Ecological speciation might be a driver in adaptive radiation, providing a framework for understanding mechanisms, level, and rate of diversification. The Arctic charr <i>Salvelinus alpinus</i> L. is a polymorphic species with huge morphological and life‐history diversity in Holarctic water systems. We studied adaptive radiation of Arctic charr ...
    • Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp. 

      Schneider, Yannik Karl-Heinz; Østnes Hansen, Kine; Isaksson, Johan; Ullsten-Wahlund, Sara Maria; Hansen, Espen; Andersen, Jeanette Hammer (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-05)
      Two bacterial isolates from the Barents Sea, both belonging to the genus <i>Algibacter</i>, were found to yield extracts with anti-bacterial bioactivity. Mass spectrometry guided dereplication and purification of the active extracts lead to the isolation of the same active principle in both extracts. The structure of the bioactive compound was identified via mass spectrometry and nuclear resonance ...
    • Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress 

      Petrovic, Voin; Nepal, Anala; Olaisen, Camilla; Bachke, Siri; Hira, Jonathan; Søgaard, Caroline Krogh; Røst, Lisa Marie; Misund, Kristine; Andreassen, Trygve; Melø, Torun Margareta; Bartosova, Zdenka; Bruheim, Per; Otterlei, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-05)
      The use of garlic and garlic-based extracts has been linked to decreased incidence of cancer in epidemiological studies. Here we examine the molecular and cellular activities of a simple homemade ethanol-based garlic extract (GE). We show that GE inhibits growth of several different cancer cells in vitro, as well as cancer growth in vivo in a syngeneic orthotopic breast cancer model. Multiple myeloma ...
    • Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis 

      Bjørn, Camilla; Håkansson, Joakim; Myhrman, Emma; Sjøstrand, Veronika; Haug, Tor; Lindgren, Kerstin; Blencke, Hans-Matti; Stensvåg, Klara; Mahlapuu, Margit (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Bacterial resistance against antibiotic treatment has become a major threat to public health. Antimicrobial peptides (AMPs) have emerged as promising alternative agents for treatment of infectious diseases. This study characterizes novel synthetic peptides sequentially derived from the AMP centrocin 1, isolated from the green sea urchin, for their applicability as anti-infective agents.The microbicidal ...
    • Anti-Infective Effect of Adhesive Probiotic Lactobacillus in Fish is Correlated with Their Spatial Distribution in the Intestinal Tissue 

      He, Suxu; Ran, Chao; Qin, Chubin; Li, Shuning; Zhang, Hongling; de Vos, Willem M.; Ringø, Einar; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-16)
      In this study, we tested the distribution of 49 Lactobacillus strains in the mucus and mucosa of the intestine tissue of zebrafish. We observed a progressive change in the spatial distribution of Lactobacillus strains, and suggested a division of the strains into three classes: mucus type (>70% in mucus), mucosa type (>70% in mucosa) and hybrid type (others). The hybrid type strains were more efficient ...
    • Antigen dose and humoral immune response correspond with protection for inactivated infectious pancreatic necrosis virus vaccines in Atlantic salmon (Salmo salar L) 

      Munang'andu, Hetron Mweemba; Fredriksen, Børge Nilsen; Mutoloki, Stephen; Dalmo, Roy Ambli; Evensen, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      An enduring challenge in the vaccinology of infectious pancreatic necrosis virus (IPNV) is the lack of correlation between neutralizing antibodies and protection against mortality. To better understand the immunological basis of vaccine protection, an efficacy trial including Atlantic salmon (Salmo salar L.) vaccinated with a high antigen (HiAg) or low antigen (LoAg) dose vaccine was carried out ...
    • The antimicrobial effect of CEN1HC-Br against Propionibacterium acnes and its therapeutic and anti-inflammatory effects on acne vulgaris 

      Han, Rui; Blencke, Hans-Matti; Cheng, Hao; Li, Chun (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-03)
      Propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. An antimicrobial peptide named CEN1HC-Br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. Little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against P. acnes. To examine the potency ...
    • Antimicrobial peptides in echinoderm host defense 

      Li, Chun; Blencke, Hans-Matti; Haug, Tor; Stensvåg, Klara (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-11-06)
      Antimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins: cysteine-rich AMPs (strongylocins) and ...
    • Antimicrobial Peptides in Echinoderms 

      Li, Chun; Haug, Tor; Stensvåg, Klara (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)