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Pain tolerance in persons with recognized and unrecognized myocardial infarction: a population-based, cross-sectional study

Permanent lenke
https://hdl.handle.net/10037/10710
DOI
https://doi.org/10.1161/JAHA.116.003846
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Åpne
article.pdf (1.067Mb)
(PDF)
Dato
2016-12-21
Type
Journal article
Tidsskriftartikkel
Peer reviewed
Article has an altmetric score of 92
Forfatter
Øhrn, Andrea Sofie Henriette Milde; Nielsen, Christopher Sivert; Schirmer, Henrik; Stubhaug, Audun; Wilsgaard, Tom; Lindekleiv, Haakon
Sammendrag
Background Unrecognized myocardial infarction (MI) is a prevalent condition associated with a similar risk of death as recognized MI. It is unknown why some persons experience MI with few or no symptoms; however, one possible explanation is attenuated pain sensitivity. To our knowledge, no previous study has examined the association between pain sensitivity and recognition of MI. Methods and Results We conducted a population‐based cross‐sectional study with 4849 included participants who underwent the cold pressor test (a common experimental pain assay) and ECG. Unrecognized MI was present in 387 (8%) and recognized MI in 227 (4.7%) participants. Participants with unrecognized MI endured the cold pressor test significantly longer than participants with recognized MI (hazard ratio for aborting the cold pressor test, 0.64; CI, 0.47–0.88), adjusted for age and sex. The association was attenuated and borderline significant after multivariable adjustment. The association between unrecognized MI and lower pain sensitivity was stronger in women than in men, and statistically significant in women only, but interaction testing was not statistically significant (P for interaction=0.14). Conclusions Our findings suggest that persons who experience unrecognized MI have reduced pain sensitivity compared with persons who experience recognized MI. This may partially explain the lack of symptoms associated with unrecognized MI.
Beskrivelse
Source:https://doi.org/10.1161/JAHA.116.003846
Forlag
Wiley Open Access. Journal of the American Heart Association
Sitering
Øhrn ASHM, Nielsen CS, Schirmer H, Stubhaug A, Wilsgaard T, Lindekleiv H. Pain tolerance in persons with recognized and unrecognized myocardial infarction: a population-based, cross-sectional study. Journal of the American Heart Association. 2016;5
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  • Artikler, rapporter og annet (klinisk medisin) [1974]

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