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    • Lifestyle changes among people with type 2 diabetes are associated with participation in online groups and time since diagnosis 

      Hansen, Anne Helen; Wangberg, Silje C.; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-12)
      <i>Background</i> - For people with Type 2 diabetes (T2D), lifestyle changes may be the most effective intervention. Online groups for people with diabetes holds a great potential to support such changes. However, little is known about the association between participation in online groups and lifestyle changes based on internet information in people with T2D. The aim of this study was to investigate ...
    • Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort 

      His, Mathilde; Viallon, Vivian; Dossus, Laure; Schmidt, Julie A.; Travis, Ruth C.; Gunter, Marc; Overvad, Kim; Kyrø, Cecilie; Tjønneland, Anne; Lécuyer, Lucie; Rothwell, Joseph A.; Severi, Gianluca; Johnson, Theron; Katzke, Verena; Schulze, Matthias B.; Masala, Giovanna; Sieri, Sabina; Panico, Salvatore; Tumino, Rosario; Macciotta, Alessandra; Boer, Jolanda M. A.; Monninkhof, Evelyn; Olsen, Karina Standahl; Nøst, Therese Haugdahl; Sandanger, Torkjel M; Agudo, Antonio; Sánchez, Maria-Jose; Amiano, Pilar; Colorado-Yohar, Sandra; Ardanaz, Eva; Vidman, Linda; Winkvist, Anna; Heath, Alicia K.; Weiderpass, Elisabete; Huybrechts, Inge; Rinaldi, Sabina (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)
      Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of ...
    • Lifestyle factors as mediators of area-level socio-economic differentials in cardiovascular disease risk factors. The Tromsø Study 

      Tiwari, Sweta; Cerin, Ester; Wilsgaard, Tom; Løvsletten, Ola; Njølstad, Inger; Grimsgaard, Sameline; Hopstock, Laila Arnesdatter; Schirmer, Henrik; Rosengren, Annika; Kristoffersen, Kathrine; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-24)
      Introduction: Cardiovascular disease (CVD) is a leading cause of death and disability and living in areas with low socio-economic status (SES) is associated with increased risk of CVD. Lifestyle factors such as smoking, physical inactivity, an unhealthy diet and harmful alcohol use are main risk factors that contribute to other modifiable risk factors, such as hypertension, raised blood cholesterol, ...
    • Lifestyle risk factors of self-reported fibromyalgia in the Norwegian Women and Cancer (NOWAC) study 

      Benebo, Faith Owunari; Lukic, Marko; Jakobsen, Monika Dybdahl; Braaten, Tonje Bjørndal (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-11)
      Background While the aetiology of fibromyalgia syndrome (FM) remains unknown, lifestyle factors have been linked to the disorder. However, there are few studies on the association between lifestyle factors and FM, thus we examine the risk of self-reported fibromyalgia given selected lifestyle factors.<p> <p>Methods We used data from 75,485 participants in the Norwegian Women and Cancer study. ...
    • Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies 

      Jayasekara, Harindra; MacInnis, Robert J.; Lujan-Barroso, Leila; Mayen-Chacon, Ana-Lucia; Cross, Amanda J.; Wallner, Bengt; Palli, Domenico; Ricceri, Fulvio; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Kühn, Tilman; Kaaks, Rudolf; Tsilidis, Konstantinos K.; Sánchez, Maria-Jose; Amiano, Pilar; Ardanaz, Eva; Chirlaque López, María Dolores; Merino, Susana; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Sternby, Hanna; Sonestedt, Emily; Bueno-de-Mesquita, Bas; Boeing, Heiner; Travis, Ruth C.; Sandanger, Torkjel M; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Tjønneland, Anne; Yang, Yi; Hodge, Allison M.; Mitchell, Hazel; Haydon, Andrew; Room, R; Hopper, John L.; Weiderpass, Elisabete; Gunter, Marc J.; Riboli, Elio; Giles, Graham G.; Milne, Roger L.; Agudo, Antonio; English, Dallas R.; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-07)
      Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne ...
    • Lifetime number of years of menstruation as a risk index for postmenopausal endometrial cancer in the Norwegian Women and Cancer Study 

      Gavrilyuk, Oxana; Braaten, Tonje; Weiderpass, Elisabete; Licaj, Idlir; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-21)
      <p><i>Introduction</i>: Lifetime number of years of menstruation (LNYM) reflects a woman's cumulative exposure to endogenous estrogen and can be used as a measure of the combined effect of reproductive factors related to endometrial cancer (EC) risk.</p> <p><i>Material and methods</i>: We aimed to study the association between LNYM and EC risk among postmenopausal women and calculate the population ...
    • Lifetime sunburn trajectories and associated risks of cutaneous melanoma and squamous cell carcinoma among a cohort of Norwegian women 

      Lergenmuller, Simon; Rueegg, Corina Silvia; Perrier, Flavie; Robsahm, Trude Eid; Green, Adele C.; Lund, Eiliv; Ghiasvand, Reza; Veierød, Marit Bragelien (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)
      Importance - To our knowledge, no study has prospectively investigated sunburn patterns over age periods from childhood to adulthood and their associations with skin cancer risk.<p> <p>Objective - To identify lifetime trajectories of sunburns and compare the association between these trajectories and subsequent risk of cutaneous melanoma and squamous cell carcinoma (cSCC).<p> <p>Design, ...
    • Lifetime ultraviolet radiation exposure and DNA methylation in blood leukocytes: The Norwegian Women and Cancer Study 

      Page, Christian; Djordjilovic, Vera; Nøst, Therese Haugdahl; Ghiasvand, Reza; Sandanger, Torkjel M; Frigessi Di Rattalma, Arnoldo; Thoresen, Magne; Veierød, Marit Bragelien (Journal article; Tidsskriftartikkel, 2020-03-11)
      Ultraviolet radiation (UVR) exposure is a leading cause of skin cancers and an ubiquitous environmental exposure. However, the molecular mechanisms relating UVR exposure to melanoma is not fully understood. We aimed to investigate if lifetime UVR exposure could be robustly associated to DNA methylation (DNAm). We assessed DNAm in whole blood in three data sets (n = 183, 191, and 125) from the Norwegian ...
    • The liminal landscape of mentoring - Stories of physicians becoming mentors 

      Valestrand, Eivind Alexander; Hokstad, Leif Martin; Schei, Edvin; Ofstad, Eirik Hugaas; Stenfors, Terese; Kvernenes, Monika (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-14)
      <p><i>Introduction:</i> This study explores narratives of physicians negotiating liminality while becoming and being mentors for medical students. Liminality is the unstable phase of a learning trajectory in which one leaves behind one understanding but has yet to reach a new insight or position. <p><i>Methods:</i> In this study, we analysed semi-structural interviews of 22 physician mentors from ...
    • Links between chemsex and reduced mental health among Norwegian MSM and other men: results from a cross-sectional clinic survey 

      Berg, Rigmor; Amundsen, Eirik; Haugstvedt, Åse (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-25)
      <i>Background</i> - The use of specific drugs to facilitate, enhance or prolong sexual sessions is referred to as ‘chemsex’. The popularity of the behavior seems to be growing, but there is a paucity of information on the mental health aspects associated with chemsex and no data on chemsex from Nordic countries. We investigated the link between chemsex and mental health among men who have sex with ...
    • Links between transactional sex and HIV/STI-risk and substance use among a large sample of European men who have sex with men 

      Berg, Rigmor; Weatherburn, Peter; Marcus, Ulrich; Schmidt, Axel J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-05)
      <i>Background</i> - In Europe, the highest proportion of HIV diagnoses are in gay men and other men who have sex with men (MSM). Globally, HIV prevalence is particularly high among males who report selling sex, but rates among men who buy sex from other men are less clear. This study analyzed the association of transactional sex (TS) and HIV diagnosis, sexually transmitted infection (STI) diagnoses, ...
    • Lipid Levels During Adult Lifetime in Men and Women With and Without a Subsequent Incident Myocardial Infarction: A Longitudinal Analysis of Data From the Tromsø Study 1974 to 2016 

      Albrektsen, Grethe; Wilsgaard, Tom; Heuch, Ivar; Løchen, Maja-Lisa; Thelle, Dag Steinar; Njølstad, Inger; Grimsgaard, Sameline; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-14)
      Background - The atherosclerotic effect of an adverse lipid profile is assumed to accumulate throughout life, leading to increased risk of myocardial infarction (MI). Still, little is known about age at onset and duration of unfavorable lipid levels before MI.<p> <p>Methods and Results - Longitudinal data on serum lipid levels for 26 130 individuals (50.5% women, aged 20–89 years) were obtained ...
    • Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer 

      Flote, Vidar Gordon; Vettukattil, Muhammad Riyas; Bathen, Tone Frost; Egeland, Thore; McTiernan, Anne; Frydenberg, Hanne; Husøy, Anders; Finstad, Sissi Espetvedt; Lømo, Jon; Garred, Øystein; Schlichting, Ellen; Wist, Erik; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)
      <b>Background:</b> High-Density Lipoprotein (HDL)-cholesterol, has been associated with breast cancer development, but the association is under debate, and whether lipoprotein subfractions is associated with breast tumor characteristics remains unclear.<br> <b>Methods:</b> Among 56 women with newly diagnosed invasive breast cancer stage I/II, aged 35–75 years, pre-surgery overnight fasting serum ...
    • LIS1-leger og medisinsk usikkerhet – en kvalitativ studie 

      Ofstad, Eirik Hugaas; Asdal, Karoline; Nightingale, Bruno; Han, Paul K.; Gregersen, Trine Ammentorp; Gulbrandsen, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)
      BAKGRUNN - Hvordan norske leger håndterer medisinsk usikkerhet, er lite studert. Formålet med studien var å undersøke hvordan leger i spesialisering del 1 (LIS1-leger) opplever og håndterer usikkerhet i en klinisk hverdag.<p> <p>MATERIALE OG METODER - Ti LIS1-leger ved to sykehus ble rekruttert til intervjuer etter svarmønsteranalyse fra et kartleggende spørreskjema. Intervjuene ble analysert ...
    • Livets sluttfase - om å finne passende behandlingsnivå og behandlingsintensitet for alvorlig syke og døende 

      Skår, Åse; Juvet, Lene Kristine; Smedslund, Geir; Bahus, Marianne Klungland; Pedersen, Reidar; Fure, Brynjar (Research report; Forskningsrapport, 2014-10)
      Etter en diskusjon i Nasjonalt råd for kvalitet og prioritering i helse- og omsorgstje-nesten i 2010, fikk Kunnskapssenteret i oppdrag å lage en rapport om tiltak som kan være til hjelp i beslutningsprosessene knyttet til begrensning av medisinsk behand-ling i livets sluttfase. Dette først og fremst med tanke på å begrense behandling av pasienter som egentlig ikke ønsker det eller har nytte av det, ...
    • Local In Time Statistics for detecting weak gene expression signals in blood – illustrated for prediction of metastases in breast cancer in the NOWAC Post-genome Cohort 

      Holden, Marit; Holden, Lars; Olsen, Karina Standahl; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-10)
      Background: Functional genomics in a processual analysis cover the time-dependent changes in transcriptomics and epigenetics before diagnosis of a disease, reflecting the changes in both life style and disease processes. The aim of this paper is to explore the dynamic, time-dependent mechanisms of the metastatic processes, using blood transcriptomics and including time in a continuous manner. For ...
    • Local management of the COVID-19 pandemic in Norway: a longitudinal interview study of municipality chief medical officers 

      Heltveit-Olsen, Silje Rebekka; Lunde, Lene; Brænd, Anja Maria; Spehar, Ivan; Høye, Sigurd; Sundvall, Pär-Daniel; Skoglund, Ingmarie; Fossum, Guro Haugen; Straand, Jørund; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-12)
      Objective - To explore the experiences and views of Norwegian Municipality Chief Medical Officers (MCMOs) on preparedness, collaboration, and organization during the COVID-19 pandemic to gain insight into local crisis management of value for future pandemic responses.<p> <p>Design - Longitudinal qualitative interview study. We conducted semi-structured digital interviews with nine MCMOs working ...
    • Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men 

      Meyer, Haakon E; Støer, Nathalie; Samuelsen, Sven Ove; Blomhoff, Rune; Robsahm, Trude Eid; Brustad, Magritt; Giovannucci, Edward L; Bjørge, Tone (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-17)
    • Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study 

      Sharashova, Ekaterina; Wilsgaard, Tom; Ball, Jocasta; Morseth, Bente; Gerdts, Eva; Hopstock, Laila Arnesdatter; Mathiesen, Ellisiv B.; Schirmer, Henrik; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-03)
      Aims To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population. Methods and results Blood pressure was measured in 8376 women and 7670 men who attended at least two of the three population-based Tromsø Study surveys conducted in 1986–87, 1994–95, and 2001. Participants were followed for ...
    • The long-term psychosocial consequences of screen-detected ductal carcinoma in situ and invasive breast cancer 

      Gram, Emma Grundtvig; Manso, Túlia Filipa Roberto; Heleno, Bruno; Siersma, Volkert; á Rogvi, Jessica; Brodersen, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-07)
      Objective - Ductal carcinoma in situ (DCIS) is a risk factor for invasive breast cancer (IBC). The prognosis of DCIS is considerably better than for IBC, yet women do not distinguish between the threat. We aimed to compare the psychosocial consequences of screen-detected DCIS and IBC, and to examine this comparison over time.<p> <p>Methods - We surveyed a Danish mammography-screening cohort from ...