Blar i forfatter Artikler, rapporter og annet (samfunnsmedisin) "Abotsi, Regina E."

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    • The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease 

      Abotsi, Regina E.; Nicol, Mark P.; McHugh, Grace; Simms, Victoria; Rehman, Andrea M.; Barthus, Charmaine; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Dube, Felix S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Nasopharyngeal (NP) swabs and sputa were ...

    • Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Nicol, Mark P.; McHugh, Grace; Simms, Victoria; Rehman, Andrea M.; Barthus, Charmaine; Mbhele, Slindile; Moyo, Brewster Wisdom; Ngwira, Lucky Gift; Mujuru, Hilda A.; Makamure, Beauty; Mayini, Justin; Odland, Jon Øyvind; Ferrand, Rashida A.; Dube, Felix S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      <b>Background</b> HIV-associated chronic lung disease (CLD) is common among children living with HIV (CLWH) in sub-Saharan Africa, including those on antiretroviral therapy (ART). However, the pathogenesis of CLD and its possible association with microbial determinants remain poorly understood. We investigated the prevalence, and antibiotic susceptibility of <i>Streptococcus pneumoniae </i>(SP), ...

    • Sputum bacterial load and bacterial composition correlate with lung function and are altered by long-term azithromycin treatment in children with HIV-associated chronic lung disease 

      Abotsi, Regina E.; Dube, Felix S.; Rehman, Andrea M.; Claassen-Weitz, Shantelle; Xia, Yao; Simms, Victoria; Mwaikono, Kilaza S.; Gardner-Lubbe, Sugnet; McHugh, Grace; Ngwira, Lucky G.; Kwambana-Adams, Brenda; Heyderman, Robert S.; Odland, Jon Øyvind; Ferrand, Rashida A.; Nicol, Mark P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)
      Background - Long-term azithromycin (AZM) treatment reduces the frequency of acute respiratory exacerbation in children and adolescents with HIV-associated chronic lung disease (HCLD). However, the impact of this treatment on the respiratory bacteriome is unknown.<p> <p>Method - African children with HCLD (defined as forced expiratory volume in 1 s z-score (FEV1z) less than − 1.0 with no ...