• Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking 

      Petrovic, Dusan; Bodinier, Barbara; Dagnino, Sonia; Whitaker, Matthew; Karimi, Maryam; Campanella, Gianluca; Nøst, Therese Haugdahl; Polidoro, Silvia; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Lund, Eiliv; Dugué, Pierre-Antoine; Giles, Graham G; Severi, Gianluca; Southey, Melissa; Vineis, Paolo; Stringhini, Silvia; Bochud, Murielle; Sandanger, Torkjel M; Vermeulen, Roel CH; Guida, Florence; Chadeau-Hyam, Marc (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-20)
      Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case–control studies, using (LASSO)-penalised ...