Blar i forfatter Artikler, rapporter og annet (samfunnsmedisin) "Dumeaux, Vanessa"

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    • Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study 

      Dumeaux, Vanessa; Børresen-Dale, Anne-Lise; Kristensen, Vessela N.; Frantzen, Jan-Ole; Kumle, Merethe; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-13)
      Introduction: The introduction of high-throughput technologies, also called -omics technologies, into epidemiology has raised the need for high-quality observational studies to reduce several sources of error and bias. Methods: The Norwegian Women and Cancer (NOWAC) postgenome cohort study consists of approximately 50,000 women born between 1943 and 1957 who gave blood samples between 2003 ...

    • Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis 

      Waaseth, Marit; Bakken, Kjersti; Dumeaux, Vanessa; Olsen, Karina Standahl; Rylander, Charlotta; Figenschaug, Yngve; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-14)
      Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT use, body mass index (BMI) and menopausal status. A secondary objective was to validate self-reported questionnaire information on menstruation and HRT use in the Norwegian Women and Cancer postgenome cohort (NOWAC). Methods: ...

    • Peripheral blood cells inform on the presence of breast cancer: A population‐based case–control study 

      Dumeaux, Vanessa; Ursini‐Siegel, Josie; Flatberg, Arnar; Fjøsne, Hans Erikssønn; Frantzen, Jan Ole; Holmen, Marit Muri; Rodegerdts, Enno; Schlichting, Ellen; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-14)
      Tumor–host interactions extend beyond the local microenvironment and cancer development largely depends on the ability of malignant cells to hijack and exploit the normal physiological processes of the host. Here, we established that many genes within peripheral blood cells show differential expression when an untreated breast cancer (BC) is present, and harnessed this fact to construct a 50-gene ...

    • The prognostic ease and difficulty of invasive breast carcinoma 

      Tofigh, Ali; Suderman, Matthew; Paquet, Eric R.; Livingstone, Julie; Bertos, Nicholas; Saleh, Sadiq M.; Zhao, Hong; Souleimanova, Margarita; Cory, Sean; Lesurf, Robert; Shahalizadeh, Solmaz; Garcia Lopez, Norberto; Riazalhosseini, Yasser; Omeroglu, Atilla; Ursini-Siegel, Josie; Park, Morag; Dumeaux, Vanessa; Hallett, Michael (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-10-02)
      Breast carcinoma (BC) has been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or those that seek to identify gene signatures with prognostic or predictive capacity. The sheer number of reported signatures has led to speculation that everything ...

    • TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations. Relation to age at diagnosis and survival 

      Dumeaux, Vanessa; Kringen, Pedro; Wang, Yun; Nesland, Jahn M.; Kristensen, Gunnar; Børresen - Dale, Anne - Lise; Dørum, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2005-10-17)
      Background: Ovarian carcinomas from 30 BRCA1 germ-line carriers of two distinct high penetrant founder mutations, 20 carrying the 1675delA and 10 the 1135insA, and 100 sporadic cases were characterized for somatic mutations in the TP53 gene. We analyzed differences in relation to BRCA1 germline status, TP53 status, survival and age at diagnosis, as previous studies have not been conclusive. Methods: ...