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dc.contributor.advisorGram, Inger Torhild
dc.contributor.advisorLicaj, Idlir
dc.contributor.authorSivertsen, Morten N.
dc.contributor.authorBåtstad, Helge S.
dc.date.accessioned2017-08-15T09:18:04Z
dc.date.available2017-08-15T09:18:04Z
dc.date.issued2017-05-14
dc.description.abstractObjective: To investigate the association between cigarette smoking and the risk of developing pancreatic cancer and if the risk differed for male- and female smokers. Methods: For our statistical analysis, using data from the Norwegian Counties Study, Cox proportional hazards model was used to obtain age-adjusted and multivariate hazard ratios with 95% confidence intervals for obtaining risk estimates for smoking and levels of smoking exposure. The multivariate analysis included covariates; age, education level, body mass index and physical activity level. Results: In multivariate analysis, the overall smoking associated risk of pancreatic cancer compared to never smokers for both sexes were similar to that of the age adjusted analysis. For the exposure variables (initiation-age, consumption, duration and cumulative amount) total years of smoking indicates the strongest association for male smokers (HR = 2.82, 95% CI = 1.87-4.24). For female smokers, early smoking initiation (≤ 19 years) gave the strongest association (HR = 3.28, 95% CI = 2.22-4.82). Female smokers showed linear trends across the different exposure categories (Ptrend < 0.05) Male smokers, had no observed linear trend for any of the exposure categories. Conclusion: Our findings conclude that there is a significant increased risk of pancreatic cancer associated with cigarette smoking. Further, we find that female smokers have a dose-response relationship between smoking and pancreatic cancer risk, which is not evident for men.en_US
dc.identifier.urihttps://hdl.handle.net/10037/11285
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2017 The Author(s)
dc.subject.courseIDHEL-3950
dc.subjectPancreatic canceren_US
dc.subjectCigarette smokingen_US
dc.subjectNorwegian Counties studyen_US
dc.subjectCohort studyen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.titleCigarette smoking and pancreatic cancer risk in 83 500 Norwegian men and womenen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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