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Effects of morphine or ketamine in rats with asphyxial cardiac arrest: a pilot study

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https://hdl.handle.net/10037/11518
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article.pdf (6.768Mb)
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Dato
2017-05-06
Type
Conference object
Konferansebidrag

Forfatter
Kuklin, Vladimir; Kondratyev, Timofey; Konkayeva, Maya; Akhatov, Nurlan; Sovershaev, Mikhail; Konkayev, Aidos; Tveita, Torkjel
Sammendrag
Acute hypoxia results in uncontrolled release of glutamate and the consequent stimulation of N-methyl-D-aspartate (NMDA) receptors, which affects the whole ionic homeostasis and finally activates apoptosis of neurons. A potential therapeutic approach to prevent this sequence of events is a blockade of NMDA receptors. Meanwhile, in different models of acute hypoxia, activation of delta-opioid receptors demonstrates significant cardioand neuroprotective effects with a consequent increase in animal survival. Thus, we aimed to test the effects of Morphine or Ketamine on hemodynamics, acid-base status and early survival in rats after asphyxia cardiac arrest (ACA).
Beskrivelse
Poster presented at the IARS 2017 Annual Meeting and International Science Symposium, May 6-9, 2017, at the Grand Hyatt Washington in Washington, DC, USA.
Forlag
UiT The Arctic University of Norway
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  • Artikler, rapporter og annet (klinisk medisin) [1974]

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