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dc.contributor.authorNothnagel, Helen
dc.contributor.authorPuta, Christian
dc.contributor.authorLehmann, Thomas
dc.contributor.authorBaumbach, Phillip
dc.contributor.authorMenard, Martha B
dc.contributor.authorGabriel, Brunhild
dc.contributor.authorGabriel, Holger HW
dc.contributor.authorWeiss, Thomas
dc.contributor.authorMusial, Frauke
dc.date.accessioned2017-11-08T08:09:09Z
dc.date.available2017-11-08T08:09:09Z
dc.date.issued2017-08-29
dc.description.abstractBackground: Quantitative sensory testing (QST) is a diagnostic tool for the assessment of the somatosensory system. To establish QST as an outcome measure for clinical trials, the question of how similar the measurements are over time is crucial. Therefore, long-term reliability and limits of agreement of the standardized QST protocol of the German Research Network on Neuropathic Pain were tested. <br>Methods: QST on the lower back and hand dorsum (dominant hand) were assessed twice in 22 healthy volunteers (10 males and 12 females; mean age: 46.6±13.0 years), with sessions separated by 10.0±2.9 weeks. All measurements were performed by one investigator. To investigate long-term reliability and agreement of QST, differences between the two measurements, correlation coefficients, intraclass correlation coefficients (ICCs), Bland–Altman plots (limits of agreement), and standard error of measurement were used. <br>Results: Most parameters of the QST were reliable over 10 weeks in healthy volunteers: Almost-perfect ICCs were observed for heat pain threshold (hand) and mechanical pain sensitivity (back). Substantial ICCs were observed for heat pain threshold (back), pressure pain threshold (back), mechanical pain sensitivity (hand), and vibration detection threshold (back and hand). Some QST parameters, such as cold detection threshold, exhibited low ICCs, but also very low variability. Generally, QST measures exhibited narrow limits of agreement in the Bland–Altman plots. <br> Conclusion: The standardized QST protocol of the German Research Network on Neuropathic Pain is feasible to be used in treatment trials. Moreover, defining a statistically meaningful change is possible, which is a prerequisite for the use of QST in clinical trials as well as in long-term investigations of disease progression.en_US
dc.descriptionSource at <a href=http://doi.org/10.2147/JPR.S137391> https://doi.org/10.2147/JPR.S137391 </a>en_US
dc.identifier.citationNothnagel H, Puta C, Lehmann T, Baumbach P, Menard MB, Gabriel B, Gabriel HHW, Weiss T, Musial F. How stable are quantitative sensory testing measurements over time? Report on 10-week reliability and agreement of results in healthy volunteers. . Journal of Pain Research. 2017;10:2067-2078en_US
dc.identifier.issn1178-7090
dc.identifier.otherFRIDAID 1495909
dc.identifier.other10.2147/JPR.S137391
dc.identifier.urihttp://hdl.handle.net/10037/11705
dc.language.isoengen_US
dc.publisherDove Pressen_US
dc.relation.journalJournal of Pain Research
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.titleHow stable are quantitative sensory testing measurements over time? Report on 10-week reliability and agreement of results in healthy volunteers.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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