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dc.contributor.authorFedirko, Veronika
dc.contributor.authorTran, Hao Quang
dc.contributor.authorGewirtz, Andrew T.
dc.contributor.authorStepien, Magdalena
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorCarbonnel, Franck
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorKühn, Tilman
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBamia, Christina
dc.contributor.authorLagiou, Pagona
dc.contributor.authorGrioni, Sara
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorCastaño, José María Huerta
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorSánchez, María-José
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorAgudo, Antonio
dc.contributor.authorSjöberg, Klas
dc.contributor.authorOhlsson, Bodil
dc.contributor.authorHemmingsson, Oskar
dc.contributor.authorWerner, Mårten
dc.contributor.authorBradbury, Kathryn E.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorAune, Dagfinn
dc.contributor.authorScalbert, Augustin
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorRiboli, Elio
dc.contributor.authorJenab, Mazda
dc.date.accessioned2018-02-09T12:56:19Z
dc.date.available2018-02-09T12:56:19Z
dc.date.issued2017-04-04
dc.description.abstractBackground:<br>Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede the development of liver cancer. However, human studies, particularly from prospective settings, are lacking.<br>Methods:<br>We used a case-control study design nested within a large prospective cohort to assess the association between circulating levels of anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) and G (IgG) (reflecting long-term exposures to LPS and flagellin, respectively) and risk of hepatocellular carcinoma. A total of 139 men and women diagnosed with hepatocellular carcinoma between 1992 and 2010 were matched to 139 control subjects. Multivariable rate ratios (RRs), including adjustment for potential confounders, hepatitis B/C positivity, and degree of liver dysfunction, were calculated with conditional logistic regression.<br>Results:<br>Antibody response to LPS and flagellin was associated with a statistically significant increase in the risk of hepatocellular carcinoma (highest vs. lowest quartile: RR = 11.76, 95% confidence interval = 1.70–81.40; P trend = 0.021). This finding did not vary substantially by time from enrollment to diagnosis, and did not change after adjustment for chronic infection with hepatitis B and C viruses.<br>Conclusions:<br>These novel findings, based on exposures up to several years prior to diagnosis, support a role for gut-derived bacterial products in hepatocellular carcinoma development. Further study into the role of gut barrier failure and exposure to bacterial products in liver diseases is warranted.en_US
dc.identifier.citationFedirko, V., Tran, H.Q., Gewirtz, A.T., Stepien, M., Trichopoulou, A., Aleksandrova, K., ... Jenab, M. Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control study. BMC Medicine. 2017;15:72:1-12en_US
dc.identifier.issn1741-7015
dc.identifier.otherFRIDAID 1489208
dc.identifier.other10.1186/s12916-017-0830-8
dc.identifier.urihttps://hdl.handle.net/10037/12116
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalBMC Medicine
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.titleExposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: A nested case-control studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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