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dc.contributor.authorRashidian, Hamideh
dc.contributor.authorHadji, Maryam
dc.contributor.authorMarzban, Maryam
dc.contributor.authorGholipour, Mahin
dc.contributor.authorRahimi-Movaghar, Afarin
dc.contributor.authorKamangar, Farin
dc.contributor.authorMalekzadeh, Reza
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorRezaianzadeh, Abbas
dc.contributor.authorMoradi, Abdolvahab
dc.contributor.authorBabhadi-Ashar, Nima
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorKhavari-Daneshvar, Hossein
dc.contributor.authorHaghdoost, Ali Akbar
dc.contributor.authorZendehdel, Kazem
dc.date.accessioned2018-02-09T14:16:56Z
dc.date.available2018-02-09T14:16:56Z
dc.date.issued2017-08-30
dc.description.abstractBackground:<br>Several case-control studies have shown associations between the risk of different cancers and self-reported opium use. Inquiring into relatively sensitive issues, such as the history of drug use, is usually prone to information bias. However, in order to justify the findings of these types of studies, we have to quantify the level of such a negative bias. In current study, we aimed to evaluate sensitivity of self-reported opioid use and suggest suitable types of control groups for case-control studies on opioid use and the risk of cancer.<br>Methods:<br>In order to compare the validity of the self-reported opioid use, we cross-validated the response of two groups of subjects 1) 178 hospitalized patients and 2) 186 healthy individuals with the results of their tests using urine rapid drug screen (URDS) and thin layer chromatography (TLC). The questioners were asked by trained interviewers to maximize the validity of responses; healthy individuals were selected from the companions of patients in hospitals.<br>Results:<br>Self-reported regular opioid use was 36.5% in hospitalized patients 19.3% in healthy individuals (p-value> 0.001).The reported frequencies of opioid use in the past 72 hours were 21.4% and 11.8% in hospitalized patients and healthy individuals respectively. Comparing their responses with the results of urine tests showed a sensitivity of 77% and 69% among hospitalized patients and healthy individuals for self-reports (p-value = 0.4). Having corrected based on the mentioned sensitivities; the frequency of opioid regular use was 47% and 28% in hospitalized patients and healthy individuals, respectively. Regular opioid use among hospitalized patients was significantly higher than in healthy individuals (p-value> 0.001).<br>Conclusion:<br>Our findings showed that the level of opioid use under-reporting in hospitalized patients and healthy individuals was considerable but comparable. In addition, the frequency of regular opioid use among hospitalized patients was significantly higher than that in the general population. Altogether, it seems that, without corrections for these differences and biases, the results of many studies including case-control studies on opioid use might distort findings substantially.en_US
dc.identifier.citationRashidian, H., Hadji, M., Marzban, M., Gholipour, M., Rahimi-Movaghar, A., Kamangar, F., ... Zendehdel, K. Sensitivity of self-reported opioid use in case-control studies: Healthy individuals versus hospitalized patients. PLoS ONE. 2017;12(8:e0183017):1-10en_US
dc.identifier.cristinIDFRIDAID 1513617
dc.identifier.doi10.1371/journal.pone.0183017
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/12121
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS ONE
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleSensitivity of self-reported opioid use in case-control studies: Healthy individuals versus hospitalized patientsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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