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dc.contributor.authorGenster, Ninette
dc.contributor.authorØstrup, Olga
dc.contributor.authorSchjalm, Camilla
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorCowland, Jack B.
dc.contributor.authorGarred, Peter
dc.date.accessioned2018-03-01T08:43:44Z
dc.date.available2018-03-01T08:43:44Z
dc.date.issued2017-06-20
dc.description.abstractFicolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection. In addition, an immune modulatory role of ficolins has been suggested. Yet, the contribution of ficolins to inflammatory disease processes remains elusive. To address this, we investigated ficolin deficient mice during a lipopolysaccharide (LPS)-induced model of systemic inflammation. Although murine serum ficolin was shown to bind LPS in vitro, there was no difference between wildtype and ficolin deficient mice in morbidity and mortality by LPS-induced inflammation. Moreover, there was no difference between wildtype and ficolin deficient mice in the inflammatory cytokine profiles after LPS challenge. These findings were substantiated by microarray analysis revealing an unaltered spleen transcriptome profile in ficolin deficient mice compared to wildtype mice. Collectively, results from this study demonstrate that ficolins are not involved in host response to LPS-induced systemic inflammation.en_US
dc.descriptionSource at <a href=https://doi.org/10.1038/s41598-017-04121-w> https://doi.org/10.1038/s41598-017-04121-w </a>.en_US
dc.identifier.citationGenster, N., Østrup, O., Schjalm, C., Mollnes, T.E., Cowland, J.B., Garred, P. (2017). Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo. Scientific Reports. 7:3852.en_US
dc.identifier.cristinIDFRIDAID 1492924
dc.identifier.doi10.1038/s41598-017-04121-w
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/12232
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalScientific Reports
dc.relation.projectIDDanish Research Council of Independent Researchen_US
dc.relation.projectIDThe Novo Nordisk Research Foundationen_US
dc.relation.projectIDThe Svend Andersen Research Foundationen_US
dc.relation.projectIDThe research Foundation of Capital Region of Denmarken_US
dc.relation.projectIDThe University of Copenhagenen_US
dc.relation.projectIDThe Odd Fellow Foundationen_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/602699/EU/Disarming the intravascular innate immune response to improve treatment modalities for chronic kidney disease/DIREKT/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectComplement cascadeen_US
dc.subjectInflammationen_US
dc.subjectPattern recognition receptorsen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.titleFicolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivoen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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