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Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study

Permanent lenke
https://hdl.handle.net/10037/12345
DOI
https://doi.org/10.1186/s12969-017-0145-5
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Åpne
article.pdf (384.6Kb)
(PDF)
Dato
2017-02-22
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Ekelund, Maria; Aalto, Kristiina; Fasth, Anders; Nielsen, Susan; Nordal, Ellen Berit; Peltoniemi, Suvi; Rygg, Marite; Zak, Marek; Berntson, Lillemor
Sammendrag
Background
To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).

Methods
In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these children. The presence of psoriasis, psoriasis-like rash, dactylitis, nail pitting, enthesitis, tenosynovitis and heredity was assessed in relation to ILAR classification and remission.

Results
Clinical findings associated with psoriasis developed consecutively during the 8-year period. Six of 14 children with psoriasis were not classified as juvenile psoriatic arthritis according to the ILAR criteria at 8 year follow-up. Dactylitis was more common in children with early onset of JIA. After 8 years we found a cumulative median number of eleven arthritic joints in children with psoriasis or psoriasis-like rash compared with six in the rest of the cohort (p = 0.02). Also, the chance for not being in remission after 8 years increased significantly in patients with psoriasis, psoriasis-like rash or at least two of: 1) first-degree heredity for psoriasis or psoriatic arthritis, 2) dactylitis or 3) nail pitting, compared with the rest of the group (OR 3.32, p = 0.010).

Conclusions
Our results indicate a more severe disease over time in psoriasis-associated JIA, as features of psoriasis develop during the disease course. This group is a major challenge to encompass in a future JIA classification in order to facilitate early tailored treatment.

Beskrivelse
Source at https://doi.org/10.1186/s12969-017-0145-5 .
Forlag
BioMed Central
Sitering
Ekelund, M., Aalto, K., Fasth, A., Herlin, T., Nielsen, S., Nordal, E.B. ... Berntson, L. (2017). Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study. Pediatric Rheumatology, 15(13).
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Samlinger
  • Artikler, rapporter og annet (klinisk medisin) [1974]

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