English
norskBlar i forfatter Artikler, rapporter og annet (Norges fiskerihøgskole) "Andersen, Aaron John Christian"
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Antimicrobial activity of small synthetic peptides based on the marine peptide turgencin A: Prediction of antimicrobial peptide sequences in a natural peptide and strategy for optimization of potency
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-30)Turgencin A, a potent antimicrobial peptide isolated from the Arctic sea squirt <i>Synoicum turgens</i>, consists of 36 amino acid residues and three disulfide bridges, making it challenging to synthesize. The aim of the present study was to develop a truncated peptide with an antimicrobial drug lead potential based on turgencin A. The experiments consisted of: (1) sequence analysis and prediction ... -
Isolation and characterization of antimicrobial peptides with unusual disulfide connectivity from the colonial ascidian Synoicum turgens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-12)This study reports the isolation of two novel cysteine-rich antibacterial peptides, turgencin A and turgencin B, along with their oxidized derivatives, from the Arctic marine colonial ascidian <i>Synoicum turgens</i>. The peptides are post-translationally modified, containing six cysteines with an unusual disulfide connectivity of Cys<sup>1</sup>-Cys<sup>6</sup>, Cys<sup>2</sup>-Cys<sup>5</sup>, and ... -
Isolation and Characterization of Antimicrobial Peptides with Unusual Disulfide Connectivity from the Colonial Ascidian Synoicum turgens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-12)This study reports the isolation of two novel cysteine-rich antibacterial peptides, turgencin A and turgencin B, along with their oxidized derivatives, from the Arctic marine colonial ascidian <i>Synoicum turgens</i>. The peptides are post-translationally modified, containing six cysteines with an unusual disulfide connectivity of Cys<sup>1</i>-Cys<sup>6</sup>, Cys<sup>2</sup>-Cys<sup>5</sup>, and ...
