• Adding zooplankton to the OSMAC toolkit: Effect of grazing stress on the metabolic profile and bioactivity of a diatom 

      Osvik, Renate Døving; Ingebrigtsen, Richard Andre; Norrbin, Fredrika; Andersen, Jeanette Hammer; Eilertsen, Hans Christian; Hansen, Espen Holst (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-03)
      “One strain many compounds” (OSMAC) based approaches have been widely used in the search for bioactive compounds. Introducing stress factors like nutrient limitation, UV-light or cocultivation with competing organisms has successfully been used in prokaryote cultivation. It is known that diatom physiology is affected by changed cultivation conditions such as temperature, nutrient concentration and ...
    • Field sampling marine plankton for biodiscovery 

      Ingebrigtsen, Richard Andre; Hansen, Espen; Andersen, Jeanette Hammer; Eilertsen, Hans Christian (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-20)
      Microalgae and plankton can be a rich source of bioactivity. However, induction of secondary metabolite production in lab conditions can be difficult. One simple way of bypassing this issue is to collect biomass in the field and screen for bioactivity. Therefore, bulk net samples from three areas along the coast of northern Norway and Spitsbergen were collected, extracted and fractionated. ...
    • Inclusion of photoautotrophic cultivated diatom biomass in salmon feed can deter lice 

      Eilertsen, Hans Christian; Elvevoll, Edel O.; Giæver, Ingeborg Hulda; Svenning, Jon Brage; Dalheim, Lars; Svalheim, Ragnhild Aven; Vang, Birthe; Siikavuopio, Sten Ivar; Dragøy, Ragnhild; Ingebrigtsen, Richard Andre; Hansen, Espen Holst; Hustad, Anette; Eilertsen, Karl-Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-29)
      The aim of this study was to evaluate the potential of diatom (microalgae) biomass as a lice-reducing ingredient in salmon feed. The original hypothesis was based on the fact that polyunsaturated aldehydes (PUAs), e.g. 2-trans, 4-trans decadenial (A3) produced by diatoms can function as grazing deterrents and harm copepod development. Salmon lice (Lepeophtheirus salmonis) is a copepod, and we intended ...
    • Mass Cultivation of Microalgae: I. Experiences with Vertical Column Airlift Photobioreactors, Diatoms and CO2 Sequestration 

      Eilertsen, Hans Christian; Eriksen, Gunilla; Bergum, John-Steinar; Strømholt, Jo; Elvevoll, Edel O.; Eilertsen, Karl-Erik; Heimstad, Eldbjørg Sofie; Giæver, Ingeborg Hulda; Israelsen, Linn; Svenning, Jon Brage; Dalheim, Lars; Osvik, Renate Døving; Hansen, Espen Holst; Ingebrigtsen, Richard Andre; Aspen, Terje M; Wintervoll, Geir-Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-17)
      From 2015 to 2021, we optimized mass cultivation of diatoms in our own developed vertical column airlift photobioreactors using natural and artificial light (LEDs). The project took place at the ferrosilicon producer Finnfjord AS in North Norway as a joint venture with UiT—The Arctic University of Norway. Small (0.1–6–14 m<sup>3</sup>) reactors were used for initial experiments and to produce inoculum ...
    • Microbial Community Dynamics during a Harmful Chrysochromulina leadbeateri Bloom in Northern Norway 

      Aalto, Nerea Johanna; Schweitzer, Hannah; Grann-Meyer, Erlend; Krsmanovic, Stina; Svenning, Jon Brage; Dalheim, Lars; Petters, Sebastian; Ingebrigtsen, Richard Andre; Hulatt, Christopher Jonathan; Bernstein, Hans Christopher (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-09)
      A harmful algal bloom occurred in late spring 2019 across multiple, interconnected fjords and bays in northern Norway. The event was caused by the haptophyte Chrysochromulina leadbeateri and led to severe fish mortality at several salmon aquaculture facilities. This study reports on the spatial and temporal succession dynamics of the holistic marine microbiome associated with this bloom by relating ...