Blar i forfatter Artikler, rapporter og annet (Norges fiskerihøgskole) "Iliev, Dimitar Borisov"

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    • Composition of exosomes derived from Atlantic salmon (Salmo salar) head kidney leukocytes 

      Strandskog, Guro; Sobhkhez, Mehrdad; Jørgensen, Jorunn B; Iliev, Dimitar Borisov (Conference object; Konferansebidrag, 2015-06-28)
      Exosomes are secreted nanosize vesicles (30−100 nm) derived from multivesicular endosomes. Exosomes are released by different immune cell types, including T- and B-lymphocytes, mast cells and antigen-presenting cells (APCs). The composition of exosomes - including protein and RNA content reflects their endosomal origin and the type of cells that produce them. Mammalian APCs produce large amounts ...

    • CpG oligonucleotides bind TLR9 and RRM-Containing proteins in Atlantic Salmon (Salmo salar) 

      Iliev, Dimitar Borisov; SkjÆveland, ingrid; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Bacterial DNA is well-known for its potent immunostimulatory properties which have been attributed to the abundance of CpG dinucleotides within the genomes of prokaryotes. Research has found that mammalian TLR9 is a receptor which mediates the immune response to CpG DNA; however, its functional properties in non-mammalian vertebrates are still poorly characterized. Leukocytes isolated ...

    • CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity 

      Iliev, Dimitar Borisov; Lagos, Leidy; Thim, Hanna Leena; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-13)
      Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs). Although activated macrophages may function as APCs, these cells are particularly effective at directly engaging pathogens through phagocytosis, and production of antimicrobial compounds. On the other hand, DCs possess superb ...

    • Intracellular distribution and transcriptional regulation of Atlantic salmon (Salmo salar) Rab5c, 7a and 27a homologs by immune stimuli 

      Nepal, Arpita; Wolfson, Deanna; Ahluwalia, Balpreet Singh; Jensen, Ingvill; Jørgensen, Jorunn B; Iliev, Dimitar Borisov (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
      Rab GTPases control trafficking of intracellular vesicles and are key regulators of endocytic and secretory pathways. Due to their specific distribution, they may serve as markers for different endolysosomal compartments. Since Rab GTPases are involved in uptake and trafficking of endocytosed ligands and cell receptors, as well as secretion of immune mediators, they have been implicated in diverse ...

    • MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes 

      Iliev, Dimitar Borisov; Sobhkhez, Mehrdad; Fremmerlid, Kjersti Kongsgården; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-10-11)
      Background: MyD88 directly interacts and affects IRF activation in mammals, but no information has been available about lower vertebrates.<p> <p>Results: Transgenic MyD88 interacts with IRF3 and IRF7A/B and modulates the IRF-induced IFN response and accumulates in aggresomes in Atlantic salmon. <p>Conclusion: MyD88 is involved in the regulation of the IRF-induced IFN response in Atlantic ...

    • Stimulation of exosome release by extracellular DNA is conserved across multiple cell types 

      Iliev, Dimitar Borisov; Strandskog, Guro; Nepal, Arpita; Aspar, Augusta; Olsen, Randi; Jørgensen, Jorunn B; Wolfson, Deanna; Ahluwalia, Balpreet Singh; Handzhiyski, Jordan; Mironova, Roumyana (Journal article; Tidsskriftartikkel; Manuskript; Peer reviewed; Preprint, 2018-06-28)
      Exosomes are distinguished from other types of extracellular vesicles by their small and relatively uniform size (30-100 nm) and their composition which reflects their endo-lysosomal origin. Involvement of these extracellular organelles in intercellular communication and their implication in pathological conditions has fuelled intensive research on mammalian exosomes; however, currently, very little ...

    • Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts 

      Sobhkhez, Mehrdad; Skjesol, Astrid; Thomassen, Ernst Ivan; Iliev, Dimitar Borisov; Sun, Baojian; Robertsen, Børre; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, description of their functional activity in lower vertebrates is still scarce. In the present study we ...