Blar i forfatter Artikler, rapporter og annet (Norges fiskerihøgskole) "Thim, Hanna Leena"
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CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity
Iliev, Dimitar Borisov; Lagos, Leidy; Thim, Hanna Leena; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-13)Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs). Although activated macrophages may function as APCs, these cells are particularly effective at directly engaging pathogens through phagocytosis, and production of antimicrobial compounds. On the other hand, DCs possess superb ... -
Homing of Antigen-Presenting Cells in Head Kidney and Spleen – Salmon Head Kidney Hosts Diverse APC Types
Iliev, Dimitri Borisov; Thim, Hanna Leena; Lagos, Leidy; Olsen, randi; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Lymph nodes and spleen are major organs where mammalian antigen-presenting cells (APCs) initiate and orchestrate Ag-specific immune responses. Unlike mammals, teleosts lack lymph nodes and an interesting question is whether alternative organs may serve as sites for antigen presentation in teleosts. In the current study, fluorescent ovalbumin (Ova) and CpG oligonucleotides (ODNs) injected intra-abdominally ... -
Profiling Atlantic salmon B cell populations: CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression
Jenberie, Shiferaw; Thim, Hanna Leena; Sunyer, J Oriol; Skjødt, Karsten; Jensen, Ingvill; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-23)While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM<sup>+</sup> cells. Of the two receptors recognizing CpG in teleosts, <i>tlr9</i> was the ... -
Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection
Jenberie, Shiferaw; Penaranda, Ma Michelle Demogina; Thim, Hanna Leena; Styrvold, Morten Bay; Strandskog, Guro; Jørgensen, Jorunn B; Jensen, Ingvill (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-10)B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon (<i>Salmo salar</i>) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal ... -
Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar).
Shi, Cheng-Yin; Skjesol, Astrid; Hansen, Tom Egil; Thim, Hanna Leena; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Vaccine adjuvants in fish vaccines make a difference: comparing the effects of three adjuvants (Montanide ISA763A oil, CpG/poly I:C combo and VHSV glycoprotein) used alone or in combination to formulate an inactivated salmonid alphavirus whole virus antigen
Thim, Hanna Leena; Villoing, Stéphane; McLoughlin, Marian F; Cristie, Karen Elina; Grove, Søren; Frost, Petter; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)