• Analysis of bacterial diversity in the intestine of grass carp (Ctenopharyngodon idellus) based on 16S rDNA gene sequences 

      Han, A; Ringø, Einar; Liu, Yuchan; Zhou, Zhigang; He, Suxu; Cao, Yanan; Bin, Yao (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
    • Anti-Infective Effect of Adhesive Probiotic Lactobacillus in Fish is Correlated with Their Spatial Distribution in the Intestinal Tissue 

      He, Suxu; Ran, Chao; Qin, Chubin; Li, Shuning; Zhang, Hongling; de Vos, Willem M.; Ringø, Einar; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-16)
      In this study, we tested the distribution of 49 Lactobacillus strains in the mucus and mucosa of the intestine tissue of zebrafish. We observed a progressive change in the spatial distribution of Lactobacillus strains, and suggested a division of the strains into three classes: mucus type (>70% in mucus), mucosa type (>70% in mucosa) and hybrid type (others). The hybrid type strains were more efficient ...
    • Bacterial Diversity in the Digestive Tracts of Four Indian Air-Breathing Fish Species Investigated by PCR Based Denaturing Gradient Gel Electrophoresis 

      He, Suxu; Zhou, Zhigang; Banerjee, Goutam; Huang, Lu; Ray, Arun Kumar; Ringø, Einar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-02)
      An investigation was conducted to identify the allochthonous microbiota (entire intestine) and the autochthonous microbiota in proximal intestine (PI) and distal intestine (DI) of four species of Indian air-breathing fish (climbing perch; Anabas testudineus, murrel; Channa punctatus, walking catfish; Clarias batrachus and stinging catfish; Heteropneustes fossilis) by PCR based denaturing gradient ...
    • Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish 

      Ding, Qianwen; Lu, Chenyao; Hao, Qiang; Zhang, Qingshuang; Yang, Yalin; Olsen, Rolf Erik; Ringø, Einar; Ran, Chao; Zhang, Zhen; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-23)
      uccinate is widely used in the food and feed industry as an acidulant, flavoring additive, and antimicrobial agent. This study investigated the effects of dietary succinate on growth, energy budget, nutritional metabolism, protein succinylation, and gut microbiota composition of zebrafish. Zebrafish were fed a control-check (0% succinate) or four succinate-supplemented diets (0.05, 0.10, 0.15, and ...
    • Dietary supplementation of exopolysaccharides from Lactobacillus rhamnosus GCC-3 improved the resistance of zebrafish against spring viremia of carp virus infection 

      Xie, Mingxu; Li, Yu; Olsen, Rolf Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      Spring viremia of carp virus (SVCV) can cause high mortality of fish. The aim of this study was to investigate the effects of Lactobacillus rhamnosus GCC-3 exopolysaccharides (GCC-3 EPS) on zebrafish (Danio rerio) infected with SVCV and elucidate the underlying mechanisms. Zebrafish were fed with a control diet or diet supplemented with 0.5% and 1% of GCC-3 EPS for 2 weeks. The results showed ...
    • Effect of dietary components on the gut microbiota of aquatic animals. A never-ending story? 

      Ringø, Einar; Zhou, Zhigang; Vecino, Jose L. González; Wadsworth, Simon L.; Romero, Jaime; Krogdahl, Åshild; Olsen, Rolf Erik; Dimitroglou, Arkadios; Foey, Andrew David; Davies, Simon; Owen, Matthew A.G.; Lauzon, Hélène Liette; Martinsen, Lisbeth Løvmo; De Schryver, Peter; Bossier, Peter; Sperstad, Sigmund; Merrifield, Daniel Lee (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-07)
      It is well known that healthy gut microbiota is essential to promote host health and well-being. The intestinal microbiota of endothermic animals as well as fish are classified as autochthonous or indigenous, when they are able to colonize the host’s epithelial surface or are associated with the microvilli, or as allochthonous or transient (associated with digesta or are present in the lumen). ...
    • Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in tilapia 

      Liu, Wenshu; Ran, Chao; Liu, Zhi; Gao, Qian; Xu, Shude; Ringø, Einar; Myklebust, Reidar; Gu, Zemao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-20)
      This study addressed the effects of dietary Lactobacillus plantarum or/and N-acylated homoserine lactonase (AHL lactonase) on controlling Aeromonas hydrophila infection in juvenile hybrid tilapia (Oreochromis niloticus♀ × O. aureus ♂). Fish were fed Lb. plantarum subsp. plantarum strain JCM1149 (108 CFU/g feed) or/and AHL lactonase AIO6 (4 U/g) and were exposed to a chronic challenge of A. hydrophila ...
    • Effects of nuclease-treated fermentation product of Lactobacillus rhamnosus GCC-3 on growth, hepatic health and gut microbiota of zebrafish (Danio rerio) fed a high-fat diet 

      Xie, Mingxu; Li, Ming; Hao, Qiang; Olsen, Rolf-Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-12)
      Probiotics are reported to improve the nutrition, immunity, and health of fish. Nuclease can hydrolyze nucleic acids of probiotics to produce nucleotides. The present study investigated the effect of stabilized fermentation product of nuclease-treated <i>Lactobacillus rhamnosus</i> GCC-3 (GCC-3 NT) on growth, non-specific immunity, liver health, and gut microbiota of zebrafish (<i>Danio rerio</i>). ...
    • Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish 

      Ding, Qianwen; Hao, Qiang; Zhang, Qingshuang; Yang, Yalin; Olsen, Rolf Erik; Ringø, Einar; Ran, Chao; Zhang, Zhen; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-28)
      Being highly unsaturated, n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) are prone to lipid peroxidation. In this study, zebrafish were fed with low-fat diet (LFD), high-fat diet (HFD), or 2% DHA-supplemented HFD (HFDHA2.0). To study the possible negative effects of the high level of dietary DHA, growth rates, blood chemistry, liver histology, hepatic oxidative stress, apoptosis, and ...
    • Growth performance, hepatic enzymes, and gut health status of common carp (Cyprinus carpio) in response to dietary Cetobacterium somerae fermentation product 

      Xie, Mingxu; Hao, Qiang; Olsen, Rolf Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-15)
      Intensive aquaculture practices compromise the health of fish. Probiotics especially those isolated from aquatic animals play important roles in improving fish health. The aim of the study was to evaluate the effects of stabilized fermentation product of Cetobacterium somerae (XMX-1) on the growth performance, gut and liver health of common carp. A total of 300 carps (initial weight of 2.32 ± 0.02 ...
    • Histological and bacteriological changes in intestine of beluga (Huso huso) following ex vivo exposure to bacterial strains 

      Salma, Wahida; Zhou, Zhigang; Wang, Wenwan; Askarian, Fatemeh; Kousha, Armin; Ebrahimi, Maryam Tajabadi; Myklebust, Reidar; Ringø, Einar (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In the present study the intestinal sac method (ex vivo) was used to evaluate the interactions between lactic acid bacteria and staphylococci in the gastrointestinal (GI) tract of beluga (Huso huso). The distal intestine (DI) of beluga was exposed ex vivo to Staphylococcus aureus, Leuconostoc mesenteroides and Lactobacillus plantarum. Histological changes following bacterial exposure were assessed ...
    • Nuclease-Treated Stabilized Fermentation Product of Cetobacterium somerae Improves Growth, Non-specific Immunity, and Liver Health of Zebrafish (Danio rerio) 

      Xie, Mingxu; Hao, Qiang; Xia, Rui; Olsen, Rolf Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-06)
      High-fat diets (HFD) are harmful to fish health. Probiotics are commonly utilized to improve fish nutrition metabolism, immune response, and health. Nucleic acids of the probiotic bacterium can be hydrolyzed by nuclease to generate nucleotides. The present study aimed to evaluate the effects of stabilized fermentation product of nucleasetreated Cetobacterium somerae XMX-1 [XMX-1 (N)] on growth, ...
    • Progress in fish gastrointestinal microbiota research 

      Wang, An R; Ran, Chao; Ringø, Einar; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-02)
      The gastrointestinal (GI) microbiota of vertebrates plays critical roles in nutrition, development, immunity and resistance against invasive pathogens. In the past decade, research of the GI microbiota of mammals has drastically increased our knowledge on the microbiota and their relationship with health and disease. However, our understanding of fish intestinal microbiota is limited. This ...
    • Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage 

      Zhang, Hongling; Ran, Chao; Teame, Tsegay; Ding, Qianwen; Hoseinifar, Seyed Hossein; Xie, Mingxu; Zhang, Zhen; Yang, Yalin; Olsen, Rolf Erik; Gatlin, Delbert M; Ringø, Einar; Duan, Ming; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-05)
      The intestinal mucosal barrier plays a critical role in the maintenance of host health. In farmed teleost fish, the intestinal epithelium is challenged by a number of factors, leading to damage of the intestinal mucosal barrier. The pathogenesis of intestinal mucosal barrier damage in most farmed teleost fish has been associated with cell death, mainly including apoptosis, pyroptosis, necroptosis ...