Show simple item record

dc.contributor.advisorŠkalko-Basnet, Nataša
dc.contributor.advisorStensrud, Gry
dc.contributor.authorHemmingsen, Lisa Myrseth
dc.date.accessioned2018-05-22T13:26:57Z
dc.date.available2018-05-22T13:26:57Z
dc.date.issued2015-05-13
dc.description.abstractChronic wounds are often colonized with biofilm-producing bacteria, such as Staphylococcus epidermidis, and these wounds often have high degree of complexity and are often challenging to treat. There is a high resistance to the traditional antimicrobial treatments and that is why these infections sometimes are persistent. Photodynamic therapy (PDT) is proposed as a potential solution to the problems of biofilm wound infection. A New Chemical Entity (NCE) together with chitosan lecithin nanoparticles were investigated for potential biofilm elimination. The NCE was entrapped in particles (approximately 350-400 nm) and this resulted in approximately 12 % entrapment. The zeta potential of the NCE-containing nanoparticles was measured to be approximately 10 mV at a pH of just below 3. To evaluate the antimicrobial effect of the NCE in a free form and the NCE-containing nanoparticles the biofilm elimination studies were carried out in both planktonic bacteria and bacteria in biofilm. In addition to evaluation of the NCE exposed to light, an assessment of the NCE without light exposure and empty nanoparticles was performed. The NCE showed a potential as a photodynamic agent, but the biofilm testing conditions need to be optimized prior to further studies.en_US
dc.identifier.urihttps://hdl.handle.net/10037/12757
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 The Author(s)
dc.subject.courseIDFAR-3901en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Biopharmacy: 736en_US
dc.titleChitosan Lecithin Nanoparticles with New Chemical Entity. Antimicrobial Evaluationen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record