Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of ...

Studies have shown that fatty acids from fish and fish oils, like eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA) may have a beneficial role in cancer by inhibiting proliferation or inducing apoptosis of the cancer cells. Several mechanisms involving different metabolites (eicosanoids) of the fatty acids have been suggested for the anti-cancer actions, but the detailed effects are still ...

BACKGROUND: Dyslipidaemia is more frequent in solid organ transplant recipients than in the general population. In order to reduce the overall cardiovascular risk in transplant patients lipid-lowering drugs, especially statins, have become widely used. However, the use of statins in transplant recipients taking cyclosporine A (CsA) results in significantly increased risk for statin induced side-effects ...

Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ...

Antimicrobial resistance (AMR) has emerged as one of the greatest threats to public health in the 21st century. Especially, the production of -lactamase enzymes has become the leading cause of -lactam resistance in Gram-negative pathogens. In addition, many of the pathogens associated with extensive antimicrobial resistance form biofilms, which further increases their persistence. Studies from ...

Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance. Virtually all Burkholderia species are also resistant to polymyxin, prohibiting use of drugs like colistin that are available for treatment of infections caused by most other drug resistant Gram-negative bacteria. Despite clinical ...

Wound healing is a complex and highly regulated process, vital for preserving the barrier function of the skin. However, several underlying pathologies have the ability to influence the cascade of events involved in this process, resulting in the development of chronic wounds. The heterogeneous nature of chronic wounds increases the requirements of novel wound dressings. Hence, the development of ...

The physical stability is crucial in formulating liposomes for drug delivery applications. The objective of the present study was to develop and evaluate the electrospun amphiphilic nanofibers intended for the templates and delivery of drug-loaded liposomes. This approach exploits the hydration of phospholipids deposited on electrospun nanofibers for the formation of liposomes, and the strategy was ...

Background - The clonal diversity underpinning trends in multidrug resistant Escherichia coli causing bloodstream infections remains uncertain. We aimed to determine the contribution of individual clones to resistance over time, using large-scale genomics-based molecular epidemiology.<p> <p>Methods - This was a longitudinal, E coli population, genomic, cohort study that sampled isolates from ...