Blar i tittel Institutt for farmasi
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Safety and efficiency of a new generic package labelling: A before and after study in a simulated setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-20)Background: Medication errors are frequent and may cause harm to patients and increase healthcare expenses. <p> Aim: To explore whether a new labelling influences time and errors when preparing medications in accordance with medication charts in an experimental setting. <p> Method: We carried out an uncontrolled before and after study with 3 months inbetween experiments. Phase I used original ... -
Salmon louse infestation levels on sea trout can be predicted from a hydrodynamic lice dispersal model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)1. The abundance of the parasitic salmon louse has increased with the growth in aquaculture of salmonids in open net pens. This represents a threat to wild salmonid populations as well as a key limiting factor for salmon farming. The Norwegian ‘traffic light’ management system for salmon farming aims to increase aquaculture production while securing sustainable wild salmonid populations. However, ... -
Samtidig bruk av warfarin og smertestillende legemidler
(Master thesis; Mastergradsoppgave, 2008-06-06)Sammendrag Bakgrunn På grunn av sitt smale terapeutiske vindu har warfarin et stort interaksjonspotensiale med både mat og andre legemidler, noe som kan øke risikoen for blødninger. Det er kjent at uselektive NSAIDs kan interagere med warfarin, men også tilfeller med økt INR og blødninger ved bruk av andre smertestillende legemidler som paracetamol og tramadol er observert. Formål: Beskrive ... -
Scalable Analysis of Untargeted LC-HRMS Data by Means of SQL Database Archiving
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is widely used to detect chemicals with a broad range of physiochemical properties in complex biological samples. However, the current data analysis strategies are not sufficiently scalable because of data complexity and amplitude. In this article, we report a novel data analysis strategy for HRMS data founded on structured query ... -
Scientific Opinion on application (EFSA-GMO-NL-2010-77) for the placing on the market of herbicide-tolerant genetically modified cotton GHB614 × LLCotton25 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Bayer CropScience
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Scientific Opinion on applications (EFSA-GMO-UK-2008-57 and EFSA-GMO-RX-MON15985) for the placing on the market of insect-resistant genetically modified cotton MON 15985 for food and feed uses, import and processing, and for the renewal of authorisation of existing products produced from cotton MON 15985, both under Regulation (EC) No 1829/2003 from Monsanto
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Scientific Opinion on the annual post-market environmental monitoring (PMEM) report from Monsanto Europe S.A. on the cultivation of genetically modified maize MON 810 in 2012
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-06-18)Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, were found to be a promising source of novel bioactive compounds against human and fish pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). After separation into an ACN-rich phase (ACN extract) ... -
SCREENING OF GENES ENCODING POTENTIAL VIRULENCE FACTORS IN ENTEROCOCCUS FAECIUM AND GAP CLOSURE OF THE reppLG1 REPLICON CLASS PLASMID IN E. FAECIUM
(Master thesis; Mastergradsoppgave, 2014-05-20)The aims of this study were to obtain a circular map of a pLG1 replicon type plasmid in E. faecium (TUH 56-32), derived from the trans-conjugation between E. faecium (K60-39), donor and (BM4105-RF) recipient strains and also to detect the presence of and describe the prevalence of selected open reading frames (ORF) from a clinical and non-clinical collection of E. faecium and E. faecalis strains. ... -
A search for miRNAs that regulates the expression of the atypical kinases ERK3, ERK4 and MK5
(Master thesis; Mastergradsoppgave, 2013-11-27)In 2010, there were 2839 women and 13 men diagnosed with breast cancer in Norway, which was equivalent to an increase of almost 50% since 1956. The risk of developing breast cancer increases with age, and will affect one in ten women during their lifetime. Despite a substantial increase in the number of early-stage breast cancers detected due to screening-programs, there is still a need for new and ... -
The search of new negative allosteric GABAB receptor modulators using in silico and in vitro approaches
(Mastergradsoppgave; Master thesis, 2020-05-14)γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the CNS. GABA exerts its function on both ionotropic ligand-gated GABAA receptors and metabotropic GABAB G-protein coupled receptors (GPCRs). Disruption in the GABAergic system has been associated with numerous neurological and psychiatric disorders in humans. These include developmental dysfunctions, epilepsy, sleep disorders, ... -
Selection or drift: The population biology underlying transposon insertion sequencing experiments
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-25)<p>Transposon insertion sequencing methods such as Tn-seq revolutionized microbiology by allowing the identification of genomic loci that are critical for viability in a specific environment on a genome-wide scale. While powerful, transposon insertion sequencing suffers from limited reproducibility when different analysis methods are compared. From the perspective of population biology, this may be ... -
Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-06)Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a ... -
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-01-12)Objective To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs.<p> <p>Design Population based cohort study using data from the national health registers.<p> <p>Setting Denmark, Finland, Iceland, Norway, and Sweden, 1996-2007.<p> ... -
Self-medication Behavior with antibiotics: a national cross-sectional survey in Sri Lanka
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)<b><p>Background</b> Antibiotic self-medication is common in low- and middle-income countries. This study aimed to evaluate the Sri Lankan public’s knowledge about and attitudes toward antibiotic use and self-medication, and factors associated with self-medication. <b><p>Methods</b> A national cross-sectional, interviewer-administered, survey of a random household sample (N = 1100) was ... -
Self-reported medication use among coronary heart disease patients showed high validity compared with dispensing data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-24)<i>Objective</i> - To validate self-reported use of medications for secondary prevention of coronary heart disease (CHD) in a population-based health study by comparing self-report with pharmacy dispensing data, and explore different methods for defining medication use in prescription databases.<br><br> <i>Study design and setting</i> - Self-reported medication use among participants with CHD ... -
The Seralini affair: degeneration of Science to Re-Science?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-29)A paper reporting findings relevant to safety of the genetically modified (GM) maize NK603 and the herbicide Roundup (Séralini et al., Food Chem Toxicol. 50:4221–4231, 2012) was retracted against the wishes of the authors, and subsequently republished in another peer-reviewed journal (Séralini et al. Environ Sci Europe, doi:10.1186/s12302- 014-0014-5, 2014). These events exemplify a trend in which ... -
Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappa B
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Silica Nanoparticles - A Versatile Tool for the Treatment of Bacterial Infections
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)The rapid emergence of drug resistance continues to outpace the development of new antibiotics in the treatment of infectious diseases. Conventional therapy is currently limited by drug access issues such as low intracellular drug accumulations, drug efflux by efflux pumps and/or enzymatic degradation. To improve access, targeted delivery using nanocarriers could provide the quantum leap in intracellular ... -
Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-21)The prediction of the <i>in vivo</i> performance of self-nanoemulsifying drug delivery systems (SNEDDSs) is currently gaining increasing attention. Therefore, the need for reliable <i>in vitro</i> models able to assess the drug solubilization capacity of such formulations upon <i>in vitro</i> lipolysis, as well as to concomitantly evaluate <i>in vitro</i> drug permeation, has become ever so evident. ...