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Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors

Permanent lenke
https://hdl.handle.net/10037/18589
DOI
https://doi.org/10.1021/acsomega.9b00700
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article.pdf (7.455Mb)
Publisert versjon (PDF)
Dato
2020-03-06
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Eksteen, Jacobus Johannes; Ausbacher, Dominik; Vasskog, Terje; Rekdal, Øystein; Svendsen, John Sigurd Mjøen
Sammendrag
Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown.
Forlag
American Chemical Society
Sitering
Eksteen JJ, Ausbacher D, Vasskog TV, Rekdal Ø, Svendsen JS. Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors . ACS Omega. 2020;5(10):4937-4942
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  • Artikler, rapporter og annet (farmasi) [394]
Copyright 2020 American Chemical Society

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