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dc.contributor.authorØstnes Hanssen, Kine
dc.contributor.authorIsaksson, Johan
dc.contributor.authorGlomsaker, Eirin
dc.contributor.authorAndersen, Jeanette hammer
dc.contributor.authorHansen, Espen
dc.date.accessioned2018-07-04T12:21:54Z
dc.date.available2018-07-04T12:21:54Z
dc.date.issued2018-06-19
dc.description.abstractA new ecdysteroid, ponasterone F (1) and the previously reported compound ponasterone A (2) were isolated from specimens of the Arctic marine bryozoan Alcyonidium gelatinosum collected at Hopenbanken, off the coast of Edgeøya, Svalbard. The structure of 1 was elucidated, and the structure of 2 confirmed by spectroscopic methods including 1D and 2D NMR and analysis of HR-MS data. The compounds were evaluated for their ability to affect bacterial survival and cell viability, as well as their agonistic activities towards the estrogen receptors α and β. The compounds were not active in these assays. Compound 2 is an arthropod hormone controlling molting and are known to act as an allelochemical when produced by plants. Even though its structure has been previously reported, this is the first time a ponasterone has been isolated from a bryozoan. A. gelatinosum produced 1 and 2 in concentrations surpassing those expected of hormonal molecules, indicating their function as defence molecules against molting predators. This work adds to the chemical diversity reported from marine bryozoans and expanded our knowledge of the chemical modifications of the ponasteronesen_US
dc.description.sponsorshipUniversitetet i Tromsø Publication grant.en_US
dc.descriptionPublisher's version allowed, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> <p>Link to publisher's version:<a href=http://dx.doi.org/10.3390/molecules23061481>http://dx.doi.org/10.3390/molecules23061481</a>en_US
dc.identifier.citationØstnes Hanssen KØ, Isaksson JM, Glomsaker E, Andersen Jh, Hansen E. Ponasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosum. Molecules. 2018;23(6), 1481. http://dx.doi.org/10.3390/molecules23061481en_US
dc.identifier.cristinIDFRIDAID 1592312
dc.identifier.doi10.3390/molecules23061481
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/10037/13155
dc.language.isoengen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.journalMolecules
dc.relation.projectIDUniversitetet i Tromsø: Publication granten_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Marine biology: 497en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Marinbiologi: 497en_US
dc.title.alternativePonasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosumen_US
dc.titlePonasterone A and F, Ecdysteroids from the Arctic Bryozoan Alcyonidium gelatinosumen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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