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dc.contributor.authorHattrem, Magnus Nergård
dc.contributor.authorDille, Morten Johnsen
dc.contributor.authorSeternes, Tore
dc.contributor.authorEge, Thorfinn
dc.contributor.authorDraget, Kurt Ingar
dc.date.accessioned2018-07-05T12:45:28Z
dc.date.available2018-07-05T12:45:28Z
dc.date.issued2017-04-25
dc.description.abstractThe first aim of the present study was to evaluate the bioavailability of ibuprofen dispersed in a novel soft chewable formulation compared with a traditional ibuprofen tablet; its second was to map the quality of taste masking and patient product satisfaction. In a phase 1, single-center, open-label, randomized, crossover study, healthy subjects received a softchew formulation or a hard tablet (reference),both containing 100 mg ibuprofen.Serial blood samples were collected over 24 hours to assess ibuprofen bioavailability. Taste and satisfaction after chewing the novel formulation 3 or 8 times were evaluated with a questionnaire. The soft-chew formulation showed comparable bioavailability to the reference tablet. The highest peak plasma concentration was observed after 3 chews, and the relative bioavailability was approximately 8% higher compared to 8 chews. The overall flavor was well appreciated, and chewing 3 times was significantly preferred (<i>P</i> = .043) over chewing 8 times. Soft chewable drug formulations may improve compliance and potentially benefit several subpopulations who experience dysphagia.en_US
dc.description.sponsorshipVitux Pharma ASen_US
dc.descriptionSource at: <a href=http://doi.org/10.1002/cpdd.357> http://doi.org/10.1002/cpdd.357</a>en_US
dc.identifier.citationHattrem, M. N., Dille, M. J., Seternes, T., Ege, T. & Draget, K. I. (2017). The Relative Bioavailability of Ibuprofen After Administration With a Novel Soft Chewable Drug Formulation. Clinical pharmacology in drug development, 7(2), 168-176. http://doi.org/10.1002/cpdd.357en_US
dc.identifier.issn2160-763X
dc.identifier.issn2160-7648
dc.identifier.otherFRIDAID 1475531
dc.identifier.other10.1002/cpdd.357
dc.identifier.urihttps://hdl.handle.net/10037/13162
dc.language.isoengen_US
dc.publisherAmerican College of Clinical Pharmacologyen_US
dc.relation.journalClinical pharmacology in drug development
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.titleThe Relative Bioavailability of Ibuprofen After Administration With a Novel Soft Chewable Drug Formulationen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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