Show simple item record

dc.contributor.authorChristoffersen, Tore
dc.contributor.authorAhmed, Luai A.
dc.contributor.authorDaltveit, Anne Kjersti
dc.contributor.authorDennison, Elaine
dc.contributor.authorEvensen, Elin
dc.contributor.authorFurberg, Anne-Sofie
dc.contributor.authorGracia-Marco, Luis
dc.contributor.authorGrimnes, Guri
dc.contributor.authorNilsen, Ole-Andreas
dc.contributor.authorSchei, Berit
dc.contributor.authorTell, Grethe S.
dc.contributor.authorVlachopoulous, Dimitris
dc.contributor.authorWinther, Anne
dc.contributor.authorEmaus, Nina
dc.date.accessioned2018-07-20T09:31:40Z
dc.date.available2018-07-20T09:31:40Z
dc.date.issued2017-06-02
dc.description.abstract<p><i>Summary</i> The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle factors. This highlights the impact of environmental stimuli and lifestyle during growth.</p> <p><i>Purpose</i> The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents.</p> <p><i>Methods</i> We included 961 participants from the population-based Fit Futures study (2010–2011). Dual-energy X-ray absorptiometry (DXA) was used to measure bone mineral density (BMD) and bone mineral content (BMC) at femoral neck (FN), total hip (TH) and total body (TB). BMD and BMC measures were linked with birth weight and length ascertained from the Medical Birth Registry of Norway. Linear regression models were used to investigate the influence of birth parameters on BMD and BMC.</p> <p><i>Results</i> Birth weight was positively associated with BMD-TB and BMC at all sites among girls; standardized β coefficients [95% CI] were 0.11 [0.01, 0.20] for BMD-TB and 0.15 [0.06, 0.24], 0.18 [0.09, 0.28] and 0.29 [0.20, 0.38] for BMC-FN, TH and TB, respectively. In boys, birth weight was positively associated with BMC at all sites with estimates of 0.10 [0.01, 0.19], 0.12 [0.03, 0.21] and 0.15 [0.07, 0.24] for FN, TH and TB, respectively. Corresponding analyses using birth length as exposure gave significantly positive associations with BMC at all sites in both sexes. The significant positive association between birth weight and BMC-TB in girls, and birth length and BMC-TB in boys remained after multivariable adjustment.</p> <p><i>Conclusions</i> We found a positive association between birth size and BMC in adolescence. However, this association was attenuated after adjustment for weight, height and physical activity during adolescence.en_US
dc.description.sponsorshipNorthern Norway Regional Health Authoritiesen_US
dc.descriptionThis is a post-peer-review, pre-copyedit version of an article published in Archives of Osteoporosis. The final authenticated version is available online at: <a href=http://dx.doi.org/10.1007/s11657-017-0348-x> http://dx.doi.org/10.1007/s11657-017-0348-x</a>.en_US
dc.identifier.cristinIDFRIDAID 1478843
dc.identifier.doi10.1007/s11657-017-0348-x
dc.identifier.issn1862-3514
dc.identifier.urihttps://hdl.handle.net/10037/13233
dc.language.isoengen_US
dc.publisherSpringer Verlag (Germany)en_US
dc.relation.journalArchives of Osteoporosis
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectDXAen_US
dc.subjectOsteoporosisen_US
dc.subjectHumansen_US
dc.subjectBone densityen_US
dc.subjectBirth weighten_US
dc.titleThe influence of birth weight and length on bone mineral density and content in adolescence: The Tromsø Study, Fit Futuresen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record