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dc.contributor.authorRomieu, Isabelle
dc.contributor.authorFerrari, Pietro
dc.contributor.authorChajès, Véronique
dc.contributor.authorde Batlle, Jordi
dc.contributor.authorBiessy, Carine
dc.contributor.authorScoccianti, Chiara
dc.contributor.authorDossus, Laure
dc.contributor.authorBoutron, Marie Christine
dc.contributor.authorBastide, Nadia
dc.contributor.authorOvervad, Kim
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorGils, Carla H.
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorLund, Eiliv
dc.contributor.authorSkeie, Guri
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSánchez, María-José
dc.contributor.authorDuell, Eric J.
dc.contributor.authorAmiano Etxezarreta, Pilar
dc.contributor.authorBorgquist, Signe
dc.contributor.authorHallmans, Göran
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick
dc.contributor.authorKey, Timothy J.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorMurphy, Neil
dc.contributor.authorWark, Petra A.
dc.contributor.authorRiboli, Elio
dc.date.accessioned2018-07-27T09:23:09Z
dc.date.available2018-07-27T09:23:09Z
dc.date.issued2016-09-06
dc.description.abstractAlcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country‐specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person‐years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber‐rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (<18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol‐induced BC risk.en_US
dc.descriptionAccepted manuscript version. Published version available at <a href=https://doi.org/10.1002/ijc.30415> https://doi.org/10.1002/ijc.30415</a>.en_US
dc.identifier.citationRomieu, I., Ferrari, P., Chajès, V., de Batlle, J., Biessy, C., Scoccianti, C., ... Riboli, E. (2017). Fiber intake modulates the association of alcohol intake with breast cancer. International Journal of Cancer, 140(2), 316-321. https://doi.org/10.1002/ijc.30415en_US
dc.identifier.cristinIDFRIDAID 1472882
dc.identifier.doi10.1002/ijc.30415
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/13295
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectalcoholen_US
dc.subjectnutritionen_US
dc.subjectbreast canceren_US
dc.subjectepidemiologyen_US
dc.titleFiber intake modulates the association of alcohol intake with breast canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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