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dc.contributor.authorHauge, Karoline Kråkmo
dc.contributor.authorDahle, Gry
dc.contributor.authorBendz, Bjørn
dc.contributor.authorHalvorsen, Per Steinar
dc.contributor.authorAbdelnoor, Michael
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorFosse, Erik
dc.date.accessioned2018-08-02T08:27:10Z
dc.date.available2018-08-02T08:27:10Z
dc.date.issued2017-12-12
dc.description.abstract<i>Objectives</i>. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to study the inflammatory response during TAVI, and compare with the response during surgical aortic valve replacement. <i>Methods</i>. Eighteen patients undergoing transcatheter implantation, either by a transfemoral (n = 9) or transaortal (n = 9) approach were compared with eighteen patients admitted for surgical replacement. Blood samples per- and postoperatively were analysed for C3bc, terminal complement complex, myeloperoxidase, macrophage inflammatory protein-1β, monocyte chemo-attractant peptide-1, eotaxin, IL-6 and troponin-T. All markers were measured at defined time points and the areas under the curve were compared. <i>Results</i>. Activation of complement, granulocytes, monocytes and eosinophils were significantly lower in the transcatheter group as compared to the surgical group (<0.01). There was no difference in generation of troponin T and IL-6. A small difference in complement activation was observed between the transfemoral and transaortal placement of TAVI. There was no significant difference in clinical outcomes between the TAVI and surgical groups. <i>Discussion</i>. Activation and release of inflammatory markers was significantly less during with TAVI as compared to SAVR, particularly for markers associated with extracorporeal circulation. TAVI and SAVR generated the same degree of IL-6 and troponin T, indicating that the burden on the myocardial tissue was the same.en_US
dc.description.sponsorshipUniversity of Oslo Oslo University Hospitalen_US
dc.descriptionThis is the pre-print version of an article published by Taylor & Francis in Scandinavian Cardiovascular Journal on 12 December 2017, available online: <a href= http://www.tandfonline.com/10.1080/14017431.2017.1416157> http://www.tandfonline.com/10.1080/14017431.2017.1416157</a>.en_US
dc.identifier.citationHauge, K.K., Dahle, G., Bendz, B,, Halvorsen, P.S., Abdelnoor, M., Mollnes, T.E. & Fosse, E. (2017). Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement. Scandinavian Cardiovascular Journal, 52(1), 43-50. https://doi.org/10.1080/14017431.2017.1416157en_US
dc.identifier.cristinIDFRIDAID 1567251
dc.identifier.doi10.1080/14017431.2017.1416157
dc.identifier.issn1401-7431
dc.identifier.issn1651-2006
dc.identifier.urihttps://hdl.handle.net/10037/13333
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalScandinavian Cardiovascular Journal
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/SFF/223255/Norway/Centre of Molecular Inflammation Research/CEMIR/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectTranscatheter aortic valve implantationen_US
dc.subjectaortic valve replacementen_US
dc.subjectaortic stenosisen_US
dc.subjectinflammationen_US
dc.subjectsystemic inflammatory response syndromeen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.titleReduced inflammatory response by transcatheter, as compared to surgical aortic valve replacementen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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