Vis enkel innførsel

dc.contributor.authorVik, Anders
dc.contributor.authorBrodin, Ellen Elisabeth
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorBrox, Jan
dc.contributor.authorJørgensen, Lone
dc.contributor.authorNjølstad, Inger
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2018-08-17T13:12:02Z
dc.date.available2018-08-17T13:12:02Z
dc.date.issued2016-10-03
dc.description.abstract<p><i>Background</i>: Serum osteoprotegerin (OPG) is elevated in patients with chronic kidney disease (CKD) and increases with decreasing renal function. However, there are limited data regarding the association between OPG and renal function in the general population. The aim of the present study was to explore the relation between serum OPG and renal function in subjects recruited from the general population.</p> <p><i>Methods</i>: We conducted a cross-sectional study with 6689 participants recruited from the general population in Tromsø, Norway. Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equations. OPG was modelled both as a continuous and categorical variable. General linear models and linear regression with adjustment for possible confounders were used to study the association between OPG and eGFR. Analyses were stratified by the median age, as serum OPG and age displayed a significant interaction on eGFR. <p><i>Results</i>: In participants ≤62.2 years with normal renal function (eGFR ≥90 mL/min/1.73 m2) eGFR increased by 0.35 mL/min/1.73 m<sup>2</sup> (95% CI 0.13–0.56) per 1 standard deviation (SD) increase in serum OPG after multiple adjustment. In participants older than the median age with impaired renal function (eGFR <90 mL/min/1.73 m<sup>2</sup>), eGFR decreased by 1.54 (95% CI −2.06 to −1.01) per 1 SD increase in serum OPG. <p><i>Conclusions</i>: OPG was associated with an increased eGFR in younger subjects with normal renal function and with a decreased eGFR in older subjects with reduced renal function. Our findings imply that the association between OPG and eGFR varies with age and renal function.en_US
dc.descriptionThe following article: Vik, A., Brodin, E.E., Mathiesen, E.B., Brox, J., Jørgensen, L., Njølstad, I., ... Hansen, J.-B. (2017). Serum osteoprotegerin and renal function in the general population: The Tromsø Study. Clinical Kidney Journal, 10(1), 38-44. https://doi.org/10.1093/ckj/sfw095, has been accepted for publication in Clinical Kidney Journal Published by Oxford University Press. Source at <a href=https://doi.org/10.1093/ckj/sfw095> https://doi.org/10.1093/ckj/sfw095</a>. Published manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a>en_US
dc.identifier.cristinIDFRIDAID 1489854
dc.identifier.doi10.1093/ckj/sfw095
dc.identifier.issn2048-8505
dc.identifier.issn2048-8513
dc.identifier.urihttps://hdl.handle.net/10037/13474
dc.language.isoengen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.journalClinical Kidney Journal
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Nephrology, urology: 772en_US
dc.subjectestimated glomerular filtration rateen_US
dc.subjectgeneral populationen_US
dc.subjectosteoprotegerinen_US
dc.subjectrenal functionen_US
dc.subjectkidney failureen_US
dc.subjectchronicen_US
dc.subjectrenal impairmenten_US
dc.subjecttumor necrosis factor receptor 11ben_US
dc.subjectglomerular filtration rateen_US
dc.subjectestimateden_US
dc.titleSerum osteoprotegerin and renal function in the general population: The Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel