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dc.contributor.authorRinde, Ludvig Balteskard
dc.contributor.authorSmåbrekke, Birgit
dc.contributor.authorMathisen Hald, Erin
dc.contributor.authorBrodin, Ellen Elisabeth
dc.contributor.authorNjølstad, Inger
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorVik, Anders
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2018-08-20T11:33:01Z
dc.date.available2018-08-20T11:33:01Z
dc.date.issued2017-02-07
dc.description.abstractThe association between myocardial infarction (MI) and future risk of incident cancer is scarcely investigated. Therefore, we aimed to study the risk of cancer after a first time MI in a large cohort recruited from a general population. Participants in a large population-based study without a previous history of MI or cancer (n = 28,763) were included and followed from baseline to date of cancer, death, migration or study end. Crude incidence rates (IRs) and hazard ratios (HRs) for cancer after MI were calculated. During a median follow-up of 15.7 years, 1747 subjects developed incident MI, and of these, 146 suffered from a subsequent cancer. In the multivariable-adjusted model (adjusted for age, sex, BMI, systolic blood pressure, diabetes mellitus, HDL cholesterol, smoking, physical activity and education level), MI patients had 46% (HR 1.46; 95% CI: 1.21–1.77) higher hazard ratio of cancer compared to those without MI. The increased cancer incidence was highest during the first 6 months after the MI, with a 2.2-fold higher HR (2.15; 95% CI: 1.29–3.58) compared with subjects without MI. After a 2-year period without higher incidence rate, MI patients displayed 60% (HR 1.60; 95% CI: 1.27–2.03) higher HR of future cancer more than 3 years after the event. The increased IRs were higher in women than men. Patients with MI had a higher short- and long-term incidence rate of cancer compared to subjects without MI. Our findings suggest that occult cancer and shared risk factors of MI and cancer may partly explain the association.en_US
dc.description.sponsorshipK.G. Jebsen Foundationen_US
dc.descriptionThis is a post-peer-review, pre-copyedit version of an article published in European Journal of Epidemiology. The final authenticated version is available online at: <a href=https://doi.org/10.1007/s10654-017-0231-5> https://doi.org/10.1007/s10654-017-0231-5</a>.en_US
dc.identifier.citationRinde, L.B., Småbrekke, B., Hald, E.M., Brodin, E.E., Njølstad, I., Mathiesen, E.B., ... Hansen, J.-B. (2017). Myocardial infarction and future risk of cancer in the general population—the Tromsø Study. European Journal of Epidemiology, 32, 193-201. https://doi.org/10.1007/s10654-017-0231-5en_US
dc.identifier.issn0393-2990
dc.identifier.issn1573-7284
dc.identifier.otherFRIDAID 1467437
dc.identifier.other10.1007/s10654-017-0231-5
dc.identifier.urihttps://hdl.handle.net/10037/13483
dc.language.isoengen_US
dc.publisherSpringer Verlag (Germany)en_US
dc.relation.journalEuropean Journal of Epidemiology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectMyocardial infarctionen_US
dc.subjectCanceren_US
dc.subjectEpidemiologyen_US
dc.subjectRisk factorsen_US
dc.titleMyocardial infarction and future risk of cancer in the general population—the Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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