dc.contributor.author | Matejcic, Marco | |
dc.contributor.author | De Batlle, Jordi | |
dc.contributor.author | Ricci, Cristian | |
dc.contributor.author | Biessy, Carine | |
dc.contributor.author | Perrier, Flavie | |
dc.contributor.author | Huybrechts, Inge | |
dc.contributor.author | Weiderpass, Elisabete | |
dc.contributor.author | Boutron-Ruault, Marie-Christine | |
dc.contributor.author | Cadeau, Claire | |
dc.contributor.author | His, Mathilde | |
dc.contributor.author | Cox, David G. | |
dc.contributor.author | Boeing, Heiner | |
dc.contributor.author | Fortner, Renée Turzanski | |
dc.contributor.author | Kaaks, Rudolf | |
dc.contributor.author | Lagiou, Pagona | |
dc.contributor.author | Trichopoulou, Antonia | |
dc.contributor.author | Benetou, Vassiliki | |
dc.contributor.author | Tumino, Rosario | |
dc.contributor.author | Panico, Salvatore | |
dc.contributor.author | Sieri, Sabina | |
dc.contributor.author | Palli, Domenico | |
dc.contributor.author | Ricceri, Fulvio | |
dc.contributor.author | Bueno-De-Mesquita, Hendrik Bastiaan | |
dc.contributor.author | Skeie, Guri | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Sánchez, María-José | |
dc.contributor.author | Chirlaque, María-Dolores | |
dc.contributor.author | Barricarte, Aurelio | |
dc.contributor.author | Quirós, José Ramón | |
dc.contributor.author | Buckland, Genevieve | |
dc.contributor.author | van Gils, Carla H. | |
dc.contributor.author | Peeters, Petra H. | |
dc.contributor.author | Key, Timothy J. | |
dc.contributor.author | Riboli, Elio | |
dc.contributor.author | Gylling, Björn | |
dc.contributor.author | Zeleniuch-Jacquotte, Anne | |
dc.contributor.author | Gunter, Mark J. | |
dc.contributor.author | Romieu, Isabelle | |
dc.contributor.author | Chajès, Véronique | |
dc.date.accessioned | 2018-09-03T16:35:55Z | |
dc.date.available | 2018-09-03T16:35:55Z | |
dc.date.issued | 2016-12-01 | |
dc.description.abstract | Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and <i>MTHFR</i> polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (OR<sub>Q4‐Q1</sub> = 1.26; 95% CI 1.00–1.58; P<sub>trend</sub> = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (OR<sub>Q4‐Q1</sub> = 1.29; 95% CI 1.02–1.62; P<sub>trend</sub> = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation. | en_US |
dc.description.sponsorship | International Agency for Research on Cancer
European Commission
Ecumenical Project for International Cooperation
Danish Cancer Society
Ligue Contre le Cancer
Institut Gustave Roussy
Mutuelle Générale de l'Education Nationale
Institut National de la Santé et de la Recherche Médicale (INSERM)
Deutsche Krebshilfe
Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research
Hellenic Health Foundation
Italian Association for Research on Cancer (AIRC) and National Research Council
Dutch Ministry of Public Health, Welfare and Sports
Netherlands Cancer Registry
LK Research Funds
Dutch Prevention Funds
Dutch ZON (Zorg Onderzoek Nederland)
World Cancer Research Fund
Statistics Netherlands
AGAUR, Generalitat de Catalunya
Health Research Funds
Swedish Cancer Society
Swedish Scientific Council and Regional Government of Skåne and Västerbotten
Cancer Research UK
Medical Research Council
Stroke Association
British Heart Foundation
Department of Health, Food Standards Agency
Welcome Trust
World Cancer Research Funds
Institut National du Cancer
la Fondation de France
La Ligue Nationale contre le Cancer | en_US |
dc.description | This is the peer reviewed version of the following article: Matejcic, M., De Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., ... Chajès, V. (2017). Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort. <i>International Journal of Cancer</i>, 140(6), 1246-1259. https://doi.org/10.1002/ijc.30536, which has been published in final form at <a href=https://doi.org/10.1002/ijc.30536> https://doi.org/10.1002/ijc.30536</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | en_US |
dc.identifier.citation | Matejcic, M., De Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., ... Chajès, V. (2017). Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort. International Journal of Cancer, 140(6), 1246-1259. https://doi.org/10.1002/ijc.30536 | en_US |
dc.identifier.cristinID | FRIDAID 1472454 | |
dc.identifier.doi | 10.1002/ijc.30536 | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.issn | 1097-0215 | |
dc.identifier.uri | https://hdl.handle.net/10037/13639 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | International Journal of Cancer | |
dc.rights.accessRights | openAccess | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 | en_US |
dc.subject | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 | en_US |
dc.subject | plasma biomarkers | en_US |
dc.subject | folate | en_US |
dc.subject | vitamin B12 | en_US |
dc.subject | alcohol | en_US |
dc.subject | hormone receptor status | en_US |
dc.subject | MTHFR polymorphism | en_US |
dc.subject | breast cancer | en_US |
dc.title | Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |