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dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorBarupal, Dinesh Kumar
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorJenab, Mazda
dc.contributor.authorFedirko, Veronika
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorOvervad, Kim
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorTjønneland, Anne
dc.contributor.authorAffret, Aurélie
dc.contributor.authorHis, Mathilde
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKatzke, Verena
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorNaska, Androniki
dc.contributor.authorKritikou, Maria
dc.contributor.authorSaieva, Calogero
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorSantucci de Magistris, Maria
dc.contributor.authorTumino, Rosario
dc.contributor.authorFasanelli, Francesca
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorMerino, Susana
dc.contributor.authorJakszyn, Paula
dc.contributor.authorSánchez, María-José
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorNavarro, Carmen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSonestedt, Emily
dc.contributor.authorEricson, Ulrika
dc.contributor.authorMaria Nilsson, Lena
dc.contributor.authorBodén, Stina
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorKhaw, Kay-Thee
dc.contributor.authorFreisling, Heinz
dc.contributor.authorCross, Amanda J.
dc.contributor.authorRiboli, Elio
dc.contributor.authorScalbert, Augustin
dc.date.accessioned2018-09-07T10:22:29Z
dc.date.available2018-09-07T10:22:29Z
dc.date.issued2016-12-22
dc.description.abstractFlavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre‐specific validated dietary questionnaires and composition data from the Phenol‐Explorer database. During an average of 11 years of follow‐up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal = 1,298 and distal = 1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93–1.18; p‐trend = 0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.en_US
dc.description.sponsorshipThe European Commission (DG‐SANCO) The International Agency for Research on Cancer The Danish Cancer Society (Denmark) Ligue Contre le Cancer, Institut Gustave Roussy Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) German Cancer Aid German Cancer Research Center (DKFZ) Federal Ministry of Education and Research (BMBF) Deutsche Krebshilfe Deutsches Krebsforschungszentrum Federal Ministry of Education and Research (Germany) The Hellenic Health Foundation (Greece) Associazione Italiana per la Ricerca sul Cancro‐AIRC‐Italy National Research Council Dutch Ministry of Public Health, Welfare and Sports (VWS) Netherlands Cancer Registry (NKR) LK Research Funds Dutch Prevention Funds Dutch ZON (Zorg Onderzoek Nederland) World Cancer Research Fund (WCRF) Statistics Netherlands Health Research Fund ( The Health Research Funds Swedish Cancer Society Swedish Research Council and County Councils of Skåne and Västerbotten Cancer Research UK Medical Research Councilen_US
dc.descriptionThis is the peer reviewed version of the following article: Zamora-Ros, R., Barupal, D., Rothwell, J.A., Jenab, M., Fedirko, V., Romieu, I., ... Scalbert, A. (2017). Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort. International Journal of Cancer, 140(8), 1836-1844. https://doi.org/10.1002/ijc.30582, which has been published in final form at <a href=https://doi.org/10.1002/ijc.30582> https://doi.org/10.1002/ijc.30582</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationZamora-Ros, R., Barupal, D., Rothwell, J.A., Jenab, M., Fedirko, V., Romieu, I., ... Scalbert, A. (2017). Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort. International Journal of Cancer, 140(8), 1836-1844. https://doi.org/10.1002/ijc.30582en_US
dc.identifier.cristinIDFRIDAID 1472682
dc.identifier.doi10.1002/ijc.30582
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/13710
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectflavonoidsen_US
dc.subjectdieten_US
dc.subjectcolorectal canceren_US
dc.subjectprospective cohorten_US
dc.subjectEPICen_US
dc.titleDietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohorten_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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