Bian, Ka; Muppani, Naveen Reddy; Elkhadragy, Lobna; Wang, Wei; Zhang, Cheng; Chen, Tenghui; Jung, Sungyun; Seternes, Ole Morten; Long, Weiwen (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-19)
Posttranslational modifications (PTMs), such as phosphorylation and
ubiquitination, play critical regulatory roles in the assembly of DNA damage response
proteins on the DNA damage site and their activities in DNA damage repair. Tyrosyl
DNA phosphodiesterase 2 (TDP2) repairs Topoisomerase 2 (Top2)-linked DNA
damage, thereby protecting cancer cells against Top2 inhibitors-induced growth
inhibition ...