Artikler, rapporter og annet (farmasi): Nye registreringer
Viser treff 21-40 av 358
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α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-25)Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of metals or microbial contamination of products. Efforts are put in finding novel strategies in both avoiding and fighting biofilms. Biofilm control is ... -
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-18)Bacterial biofilms are highly protected surface attached communities of bacteria that typically cause chronic infections. To address their recalcitrance to antibiotics and minimise side effects of current therapies, smart drug carriers are being explored as promising platforms for antimicrobials. Herein, we briefly summarize recent efforts and considerations that have been applied in the design ... -
On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-21)ERK3 and ERK4 define a distinct and understudied subfamily of mitogen-activated protein kinases (MAPKs). Little is known about the physiological roles of these atypical MAPKs and their association with human diseases. Interestingly, accumulating evidence points towards a role for ERK3 and ERK4 signaling in the initiation and progression of various types of cancer. Notably, a recent study reported ... -
Patient perceptions and experiences with medication-related activities in the emergency department: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)Background - Emergency department (ED) pharmacists reduce medication errors and improve quality of medication use. Patient perceptions and experiences with ED pharmacists have not been studied. The aim of this study was to explore patients’ perceptions of and experiences with medication-related activities in the ED, with and without an ED pharmacist present.<p> <p>Methods - We conducted 24 ... -
The COVID-19 Pandemic Sparked off a Large-Scale Outbreak of Carbapenem-Resistant Acinetobacter baumannii from the Endemic Strains at an Italian Hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)Acinetobacter baumannii is a nosocomial pathogen that poses a serious threat due to the rise of incidence of multidrug-resistant (MDR) strains. During the COVID-19 pandemic, MDR A. baumannii clones have caused several outbreaks worldwide. Here, we describe a detailed investigation of an MDR A. baumannii outbreak that occurred at Policlinico San Matteo (Pavia, Italy). A total of 96 A. baumannii ... -
Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)Whole genome sequencing data of 874 Escherichia coli isolates carrying blaNDM-5 from 13 European Union/ European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an increasing frequency of detection. Nearly a third (30.6%) of these isolates were associated with infections and more than half (58.2%) were ... -
Evolutionary and functional history of the Escherichia coli K1 capsule
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, ... -
Early response evaluation by single cell signaling profiling in acute myeloid leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-07)Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of ... -
Lecithin and Chitosan as Building Blocks in Anti-Candida Clotrimazole Nanoparticles
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within the wound bed. However, as fungal contributions in these microbial communities become more recognized, the focus needs to be broadened, and the remaining participants in the complex wound microbiome need to be addressed in the development of new treatment ... -
A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (A ... -
Co-products from the Atlantic salmon filleting industry – Their properties, stability and potential as human food ingredients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)The present study impacts the growing knowledge about co-products obtained from the primary processing of Atlantic salmon (Salmo Salar L.) as food ingredients by highlighting their microbial and chemical composition and stability. The proximate composition varied between the co-products from the fatty belly-flap (34% lipid, 15% protein) to the leaner deboned meat (10% fat, 22% protein) (p < 0.001), ... -
Scalable Analysis of Untargeted LC-HRMS Data by Means of SQL Database Archiving
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)Liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is widely used to detect chemicals with a broad range of physiochemical properties in complex biological samples. However, the current data analysis strategies are not sufficiently scalable because of data complexity and amplitude. In this article, we report a novel data analysis strategy for HRMS data founded on structured query ... -
Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used large-scale quantitative phosphoproteomics and targeted gene silencing to identify direct ERK3 substrates ... -
Insight into the mechanism behind oral bioavailability-enhancement by nanosuspensions through combined dissolution/permeation studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-02)As numerous new drug candidates are poorly water soluble, enabling formulations are needed to increase their bioavailability for oral administration. Nanoparticles are a conceptually simple, yet resource consuming strategy for increasing drug dissolution rate, as predicting in vivo oral absorption using in vitro dissolution remains difficult. The objective of this study was to obtain insight into ... -
Strong pathogen competition in neonatal gut colonisation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-01)Opportunistic bacterial pathogen species and their strains that colonise the human gut are generally understood to compete against both each other and the commensal species colonising this ecosystem. Currently we are lacking a population-wide quantification of strain-level colonisation dynamics and the relationship of colonisation potential to prevalence in disease, and how ecological factors ... -
Targeted PFAS analyses and Extractable Organofluorine – Enhancing our Understanding of the presence of unknown PFAS in Norwegian wildlife
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)With the current possible presence of thousands of PFAS compounds in industrial emissions, there is an increasing need to assess the impacts of PFAS regulation of conventional PFAS on one hand and the exposure to emerging and yet unknown PFAS on the other. Today’s analytical methodologies using targeted approaches are not sufficient to determine the complete suite of PFAS present. To evaluate the ... -
Communication about medication management during patient-physician consultations in primary care: a participant observation study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-03)Objective - To explore communication about medication management during annual consultations in primary care. Design: passive participant observations of primary care consultations.<p> <p>Setting - Two primary care centres in southern Sweden.<p> <p>Participants - Consultations between 18 patients (over the age of 60 years) with chronic diseases and 10 general practitioners (GPs) were observed, ... -
Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less susceptible to conventional antimicrobial treatment than the planktonic bacteria. Antimicrobial peptides and their mimics are considered attractive candidates in the ... -
Potential Safety Issues With Combined Use of Dietary Supplements and Medication – Focus on Interactions
(Chapter; Bokkapittel, 2022-11-09)The use of dietary supplements (DS) is widespread and tends to increase with age and female gender. DS use can in some situations represent a safety risk for patients. For instance, concomitant use of medication and dietary supplements, particularly herbal remedies, may cause clinically significant pharmacological interactions. The study underlying this chapter aimed to investigate the prevalence ... -
Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)ABSTRACT Collateral sensitivity and resistance occur when resistance development toward one antimicrobial either potentiates or deteriorates the effect of others. Previous reports on collateral effects on susceptibility focus on newly acquired resistance determinants and propose that novel treatment guidelines informed by collateral networks may reduce the evolution, selection, and spread of ...