Gas embolism during surgery. A complement mediated condition?
Permanent link
https://hdl.handle.net/10037/13899Date
2017-10-01Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Storm, Benjamin Stage; Christiansen, Dorte; Dybwik, Knut; Mollnes, Tom Eirik; Nielsen, Erik WaageAbstract
Introduction: Venous air embolism (VAE) may arise during surgical procedures. VAE might be complicated with a systemic inflammatory response, disseminated intervascular coagulation, multi-organ failure and cardiovascular collapse. During a short time-span, three patients at our institution developed signs of VAE in conjunction with gynecological surgery. One died, one developed severe cerebral infarctions and one developed myocardial infarction.
Previously, air embolisms have been shown to trigger complement C3 and C5 activation in plasma. We have examined in vitro in human whole blood and in vivo in a porcine model, how air triggers inflammation and activation of complement and coagulation and their cross-talk.
Description
Accepted manuscript version, licensed CC BY-NC-ND 4.0. Source at: https://doi.org/10.1016/j.molimm.2017.06.196