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Prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14-16 Weeks' gestation

Permanent lenke
https://hdl.handle.net/10037/14062
DOI
https://doi.org/10.1038/s41598-018-31614-z
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Åpne
article.pdf (1.595Mb)
(PDF)
Dato
2018-09-06
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Lekva, Tove; Godang, Kristin; Michelsen, Annika E.; Qvigstad, Elisabeth; Normann, Kjersti R.; Norwitz, Errol R.; Tore, Henriksen; Bollerslev, Jens; Roland, Marie; Ueland, Thor
Sammendrag
Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14-16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study using different diagnostic criteria (WHO1999, IADPSG2010, WHO2013, NORWAY2017) and (2) develop pre-diabetes 5 years postpartum focusing on first trimester β-cell function in a separate study of 300 women from the STORK cohort. The sensitivity of the 14-16 week OGTT to identify women who would develop GDM or have LGA babies was low, and we could not identify alternative cut-offs to exclude women not at risk or identify women that could benefit from early intervention. First trimester β-cell function was a stronger determinant than third trimester β-cell function of predicting maternal pre-diabetes. In conclusion, in our normal low-risk population, the 75 g OGTT at 14-16 weeks is insufficient to identify candidates for early treatment of GDM or identify women not likely to develop GDM or have LGA babies. First trimester β-cell function may predict pre-diabetes 5 years postpartum.
Beskrivelse
Source at http://dx.doi.org/10.1038/s41598-018-31614-z
Forlag
Nature Research
Sitering
Lekva, T., Godang, K., Michelsen, A. E., Qvigstad, E., Normann, K. R., Norwitz, E. R., Aukrust, P., Henriksen, T., Bollerslev, J., Roland, M., … Ueland, T. (2018). Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14-16 Weeks' Gestation. Scientific reports, 8(1), 13392. http://dx.doi.org/10.1038/s41598-018-31614-z
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  • Artikler, rapporter og annet (klinisk medisin) [1974]

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