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dc.contributor.authorVieweg, Ireen
dc.contributor.authorBilbao, Eider
dc.contributor.authorMeador, James P.
dc.contributor.authorCancio, Ibon
dc.contributor.authorBender, Morgan Lizabeth
dc.contributor.authorCajaraville, Miren P.
dc.contributor.authorNahrgang, Jasmine
dc.date.accessioned2019-01-17T13:16:57Z
dc.date.available2019-01-17T13:16:57Z
dc.date.issued2018-03-17
dc.description.abstractPolar cod is an abundant Arctic key species, inhabiting an ecosystem that is subjected to rapid climate change and increased petroleum related activities. Few studies have investigated biological effects of crude oil on lipid metabolism in this species, despite lipids being a crucial compound for Arctic species to adapt to the high seasonality in food abundance in their habitat. This study examines the effects of dietary crude oil exposure on transcription levels of genes related to lipid metabolism (peroxisome proliferator-activated receptors [ppar-α, ppar-γ], retinoic X receptor [rxr-β], palmitoyl-CoA oxidase [aox1], cytochrome P4507A1 [cyp7α1]), reproduction (vitellogenin [vtg-β], gonad aromatase [cyp19a1]) and biotransformation (cytochrome P4501A1 [cyp1a1], aryl hydrocarbon receptor [ahr2]). Exposure effects were also examined through plasma chemistry parameters. Additional fish were exposed to a PPAR-α agonist (WY-14,643) to investigate the role of PPAR-α in their lipid metabolism. The dose-dependent up-regulation of cyp1a1 reflected the activation of genes related to PAH biotransformation upon crude oil exposure. The crude oil exposure did not significantly alter the mRNA expression of genes involved in lipid homeostasis except for cyp7α1 transcription levels. Plasma levels of cholesterol and alanine transaminase showed significant alterations in fish exposed to crude oil at the end of the experiment. WY exposure induced a down-regulation of ppar-α, an effect contrary to studies performed on other fish species. In conclusion, this study showed clear effects of dietary crude oil exposure at environmentally relevant concentrations on xenobiotic biotransformation but revealed only weak alterations in the lipid metabolism of polar cod.en_US
dc.description.sponsorshipThe EWMA project The Basque Government University of the Basque Countryen_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0.</a> Published version available at <a href=https://doi.org/10.1016/j.cbpc.2018.03.003> https://doi.org/10.1016/j.cbpc.2018.03.003</a>.en_US
dc.identifier.citationVieweg, I., Bilbao, E., Meador, J.P., Cancio, I., Bender, M.L., Cajaraville, M.P. & Nahrgang, J. (2018). Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod (<i>Boreogadus saida</i>). <i>Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology</i>, 206-207, 54-64. https://doi.org/10.1016/j.cbpc.2018.03.003en_US
dc.identifier.cristinIDFRIDAID 1573942
dc.identifier.doi10.1016/j.cbpc.2018.03.003
dc.identifier.issn1532-0456
dc.identifier.issn1878-1659
dc.identifier.urihttps://hdl.handle.net/10037/14476
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalComparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/NORDSATS/195160/Norway/Northern Environmental Waste Management//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/214184/Norway/Polar cod, lipid metabolism and disruption by polycyclic aromatic hydrocarbons//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.subjectBiotransformationen_US
dc.subjectCrude oilen_US
dc.subjectLipid metabolismen_US
dc.subjectPeroxisome proliferator-activated receptorsen_US
dc.subjectPlasma chemistryen_US
dc.subjectPolar coden_US
dc.subjectReproductionen_US
dc.titleEffects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod (Boreogadus saida)en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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