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dc.contributor.authorda Silva, Marisa Eleonor
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorLicaj, Idlir
dc.contributor.authorLissner, Lauren
dc.contributor.authorRylander, Charlotta
dc.date.accessioned2019-02-04T09:57:12Z
dc.date.available2019-02-04T09:57:12Z
dc.date.issued2018-09-11
dc.description.abstract<p><i>Background</i>: Excess body weight and weight gain have been reported to independently increase the risk of several cancers. There are few published studies in nationally representative populations of women on specific, ‘obesity-related’ cancers in relation to prior weight change and relevant confounders.</p> <p><i>Methods</i>: Based on self-reported anthropometry, we prospectively assessed body mass index (BMI), weight change over 6 years and subsequent obesity-related cancer risk in the Norwegian Women and Cancer study. We used Cox proportional hazard models to calculate hazard ratios and restricted cubic splines to model potential non-linear dose–response relationships.</p> <p><i>Results</i>: Excess body weight increased the risk of overall obesity-related cancer, postmenopausal breast, colorectal, colon, endometrial and kidney cancer, with endometrial cancer showing a threefold elevated risk. High weight gain ( ≥ 10 kg) increased the risk of overall obesity-related cancer, postmenopausal breast, endometrial and pancreatic cancer. The association between high weight gain and pancreatic cancer was strong, with 91% increased risk.</p> <p><i>Conclusions</i>: Maintaining stable weight in middle adulthood, irrespective of BMI category at baseline, and avoiding excess body weight are both important in the prevention of several obesity-related cancers in women. Our finding of increased risk of pancreatic cancer in women with moderate and high weight gain is novel.en_US
dc.description.sponsorshipUiT The Arctic University of Norwayen_US
dc.descriptionSubmitted manuscript version. Published version available at <a href=https://doi.org/10.1038/s41416-018-0240-5> https://doi.org/10.1038/s41416-018-0240-5</a>.en_US
dc.identifier.citationda Silva, M.E., Weiderpass, E., Licaj, I., Lissner, L. & Rylander, C. (2018). Excess body weight, weight gain and obesity-related cancer risk in women in Norway: the Norwegian Women and Cancer study. <i>British Journal of Cancer</i>, 119, 646-656. https://doi.org/10.1038/s41416-018-0240-5en_US
dc.identifier.cristinIDFRIDAID 1618742
dc.identifier.doi10.1038/s41416-018-0240-5
dc.identifier.issn0007-0920
dc.identifier.issn1532-1827
dc.identifier.urihttps://hdl.handle.net/10037/14597
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalBritish Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleExcess body weight, weight gain and obesity-related cancer risk in women in Norway: the Norwegian Women and Cancer studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePreprinten_US
dc.typeManuskripten_US


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