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dc.contributor.authorVitale, Jacopo Antonino
dc.contributor.authorLombardi, Giovanni
dc.contributor.authorWeydahl, Andi
dc.contributor.authorBanfi, Giuseppe
dc.date.accessioned2019-03-01T10:26:19Z
dc.date.available2019-03-01T10:26:19Z
dc.date.issued2018-06-28
dc.description.abstractRhythms can be observed at all levels of the biologic integration in humans. The observation that a biological or physiological variable shows a circadian rhythm can be explained by several multifactorial systems including external (exogenous), internal (endogenous) and psychobiological (lifestyle) mechanisms. Our body clock can be synchronized with the environment by external factors, called “synchronizers”, i.e. the light–dark cycle, but it is also negatively influenced by some pathological conditions or factors, called “chronodisruptors,” i.e. aging or low physical activity (PA). The desynchronization of a 24-h rhythm in a chronic manner has been recently defined “chronodisruption” or “circadian disruption.” A very large number of hormonal variables, such as adrenal and gonadal stress steroids, are governed by circadian rhythmicity. Such hormones, in normal conditions, show a peak in the first part of the day, while their typical diurnal fluctuations are totally out of sync in subjects affected by cancer or metabolic diseases, such as obesity, diabetes and metabolic syndrome. In general, a flatter slope with altered peaks in cortisol and testosterone circadian rhythms has been observed in pathological individuals. PA, specifically chronic exercise, seems to play a key role as synchronizer for the whole circadian system in such pathologies even if specific data on steroids circadian pattern are still sparse and contradictory. Recently, it has been proposed that low-intensity chronic PA could be an effective intervention to decrease morning cortisol levels in pathological subjects. The standardization of all confounding factors is needed to reach more clear evidence-based results.en_US
dc.description.sponsorshipItalian Ministry of Healthen_US
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in <i>Chronobiology International</i> on 28 June 2018, available online: <a href=http://www.tandfonline.com/10.1080/07420528.2018.1475395> http://www.tandfonline.com/10.1080/07420528.2018.1475395</a>.en_US
dc.identifier.citationVitale, J.A., Lombardi, G., Weydahl, A. & Banfi, G. (2018). Biological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and cancer. <i>Chronobiology International, 35</i>(9), 1185-1197. https://doi.org/10.1080/07420528.2018.1475395en_US
dc.identifier.cristinIDFRIDAID 1643737
dc.identifier.doi10.1080/07420528.2018.1475395
dc.identifier.issn0742-0528
dc.identifier.issn1525-6073
dc.identifier.urihttps://hdl.handle.net/10037/14802
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalChronobiology International
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Sports medicine: 850en_US
dc.subjectVDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850en_US
dc.subjectCircadian rhythmen_US
dc.subjectsynchronizeren_US
dc.subjectphysical activityen_US
dc.subjectinflammationen_US
dc.subjectcanceren_US
dc.titleBiological rhythms, chronodisruption and chrono-enhancement: The role of physical activity as synchronizer in correcting steroids circadian rhythm in metabolic dysfunctions and canceren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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