ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraaknorsk 
    • EnglishEnglish
    • norsknorsk
  • Administrasjon/UB
Vis innførsel 
  •   Hjem
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • Vis innførsel
  •   Hjem
  • Det helsevitenskapelige fakultet
  • Institutt for klinisk medisin
  • Artikler, rapporter og annet (klinisk medisin)
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects

Permanent lenke
https://hdl.handle.net/10037/14860
DOI
https://doi.org/10.1530/EC-18-0144
Thumbnail
Åpne
article.pdf (701.2Kb)
Publisher's version (PDF)
Dato
2018-06
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Kubiak, Julia Magdalena; Thorsby, Per Medbøe; Kamycheva, Elena; Jorde, Rolf
Sammendrag

Objective: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies, the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D-sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D-insufficient subjects.

Design: Double-blinded randomized controlled trial.

Methods: A 4-month interventional study with high-dose vitamin D (100,000 IU loading dose, followed by 20,000 IU/week) or placebo with measurements of blood pressure, lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B), and glucose metabolism parameters (blood glucose, HbA1c, serum human receptors for advanced glycation end products (sRAGE), insulin, C-peptide and HOMA-IR).

Results: A total of 422 subjects with mean serum 25(OH)D level 34 nmol/L were included, with 411 subjects completing the study. Serum 25(OH)D levels increased with 56 nmol/L and decreased with 4 nmol/L in the vitamin D and placebo group, respectively. We found no statistically significant differences between the two groups in any of the measured CVD risk factors, except for a minor increase in sRAGE in the vitamin D group. Stratified analyses of subjects with low baseline serum 25(OH)D levels alone, or combined with blood pressure, lipid and HOMA-IR values above the median for the cohort, did not skew the results in favour of vitamin D supplementation.

Conclusion: Supplementation with vitamin D in subjects with baseline vitamin D insufficiency does not improve CVD risk factor profile.

Beskrivelse
The following article, Kubiak, J., Thorsby, P.M., Kamycheva, E. & Jorde, R. (2018). Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects. Endocrine Connections, 7(6), 840-849, can be accessed at https://doi.org/10.1530/EC-18-0144.
Forlag
BioScientifica
Sitering
Kubiak, J., Thorsby, P.M., Kamycheva, E. & Jorde, R. (2018). Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects. Endocrine Connections, 7(6), 840-849. https://doi.org/10.1530/EC-18-0144
Metadata
Vis full innførsel
Samlinger
  • Artikler, rapporter og annet (klinisk medisin) [1974]

Bla

Bla i hele MuninEnheter og samlingerForfatterlisteTittelDatoBla i denne samlingenForfatterlisteTittelDato
Logg inn

Statistikk

Antall visninger
UiT

Munin bygger på DSpace

UiT Norges Arktiske Universitet
Universitetsbiblioteket
uit.no/ub - munin@ub.uit.no

Tilgjengelighetserklæring