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dc.contributor.authorPlato, Nils
dc.contributor.authorMartinsen, Jan Ivar
dc.contributor.authorKjærheim, Kristina
dc.contributor.authorKyyrönen, Pentti
dc.contributor.authorSparen, Pär
dc.contributor.authorWeiderpass, Elisabete
dc.date.accessioned2019-03-18T12:29:20Z
dc.date.available2019-03-18T12:29:20Z
dc.date.issued2018-04-21
dc.description.abstract<i>Background</i>: There is little information on the doseeresponse relationship between exposure to occupational carcinogenic agents and mesothelioma. This study aimed to investigate this association as well as the existence of agents other than asbestos that might cause mesothelioma.<p> <p><i>Methods</i>: The Swedish component of the Nordic Occupational Cancer (NOCCA) study consists of 6.78 million individuals with detailed information on occupation. Mesothelioma diagnoses recorded in 1961e 2009 were identified through linkage to the Swedish Cancer Registry. We determined cumulative exposure, time of first exposure, and maximum exposure intensity by linking data on occupation to the Swedish NOCCA job-exposure matrix, which includes 29 carcinogenic agents and corresponding exposure for 283 occupations. To assess the risk of mesothelioma, we used conditional logistic regression models to estimate hazard ratios and 95% confidence intervals.<p> <p><i>Results</i>: 2,757 mesothelioma cases were identified in males, including 1,416 who were exposed to asbestos. Univariate analyses showed not only a significant excess risk for maximum exposure intensity, with a hazard ratio of 4.81 at exposure levels 1.25e2.0 fb/ml but also a clear doseeresponse effect for cumulative exposure with a 30-, 40-, and 50-year latency time. No convincing excess risk was revealed for any of the other carcinogenic agents included in the Swedish NOCCA job-exposure matrix.<p> <p><i>Conclusion</i>: When considering asbestos exposure, past exposure, even for short periods, might be enough to cause mesothelioma of the pleura later in life.<p>en_US
dc.description.sponsorshipNordic Cancer Union, Helsinki, Finland AFA Insurance (AFA Försäkring dnr 100294), Stockholm, Swedenen_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.shaw.2018.04.003>https://doi.org/10.1016/j.shaw.2018.04.003. </a>en_US
dc.identifier.citationPlato, N., Martinsen, J.I., Kjærheim, K., Kyyrönen, P., Sparen, P. & Weiderpass, E. (2018). Mesothelioma in Sweden: Dose–Response Analysis for Exposure to 29 Potential Occupational Carcinogenic Agents. <i>Safety and Health at Work, 9</i>(3), 290-295. https://doi.org/10.1016/j.shaw.2018.04.003en_US
dc.identifier.issn2093-7911
dc.identifier.issn2093-7997
dc.identifier.otherFRIDAID 1592712
dc.identifier.other10.1016/j.shaw.2018.04.003
dc.identifier.urihttps://hdl.handle.net/10037/15014
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalSH@W Safety and Health at Work
dc.rights.accessRightsopenAccessen_US
dc.subjectAsbestosen_US
dc.subjectDoseeresponseen_US
dc.subjectMesotheliomaen_US
dc.subjectPleuraen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleMesothelioma in Sweden: Dose–Response Analysis for Exposure to 29 Potential Occupational Carcinogenic Agentsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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