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dc.contributor.authorWessel, Øystein
dc.contributor.authorKrasnov, Aleksei
dc.contributor.authorTimmerhaus, Gerrit
dc.contributor.authorRimstad, Espen
dc.contributor.authorDahle, Maria
dc.date.accessioned2019-03-27T10:51:15Z
dc.date.available2019-03-27T10:51:15Z
dc.date.issued2019-01-16
dc.description.abstractSalmonid red blood cells are the main target cells for <i>Piscine orthoreovirus</i> (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (<i>Salmo salar</i>), Chinook salmon (<i>Onchorhynchus tshawytscha</i>), Coho salmon (<i>Oncorhynchus kisutch</i>), rainbow trout (<i>Onchorhynchus mykiss</i>) and brown trout (<i>Salmo trutta</i>), and can cause diseases like heart and skeletal muscle inflammation (HSMI), jaundice syndrome, erythrocyte inclusion body syndrome (EIBS) and proliferative darkening syndrome (PDS). Purified PRV administrated to fish has proven the causality for HSMI and EIBS. During the early peak phase of infection, salmonid erythrocytes are the main virus-replicating cells. In this initial phase, cytoplasmic inclusions called “virus factories” can be observed in the erythrocytes, and are the primary sites for the formation of new virus particles. The PRV-infected erythrocytes in Atlantic salmon mount a strong long-lasting innate antiviral response lasting for many weeks after the onset of infection. The antiviral response of Atlantic salmon erythrocytes involves upregulation of potential inhibitors of translation. In accordance with this, PRV-1 protein production in erythrocytes halts while virus RNA can persist for months. Furthermore, PRV infection in Coho salmon and rainbow trout are associated with anemia, and in Atlantic salmon lower hemoglobin levels are observed. Here we summarize and discuss the recently published findings on PRV infection, replication and effects on salmonid erythrocytes, and discuss how PRV can be a useful tool for the study of innate immune responses in erythrocytes, and help reveal novel immune functions of the red blood cells in fish.en_US
dc.descriptionThe following article, Wessel, Ø.W., Krasnov, A., Timmerhaus, G.F., Rimstad, E. & Dahle, M.K. (2019). Antiviral Responses and Biological Concequences of <i>Piscine orthoreovirus</i> Infection in Salmonid Erythrocytes. <i>Frontiers in Immunology, 9</i>, can be accessed at <a href=https://doi.org/10.3389/fimmu.2018.03182> https://doi.org/10.3389/fimmu.2018.03182</a>.en_US
dc.identifier.citationWessel, Ø.W., Krasnov, A., Timmerhaus, G.F., Rimstad, E. & Dahle, M.K. (2019). Antiviral Responses and Biological Concequences of <i>Piscine orthoreovirus</i> Infection in Salmonid Erythrocytes. <i>Frontiers in Immunology, 9</i>. https://doi.org/10.3389/fimmu.2018.03182en_US
dc.identifier.issn1664-3224
dc.identifier.otherFRIDAID 1685998
dc.identifier.other10.3389/fimmu.2018.03182
dc.identifier.urihttps://hdl.handle.net/10037/15079
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Immunology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/237315/Norway/Fish Virus Vaccines/ViVaFish/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/280847/Norway/Comparing the protection of attenuated and inactivated virus vaccines against pancreas disease and heart and skeletal muscle inflammation//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectPiscine orthoreovirusen_US
dc.subjectred blood cellsen_US
dc.subjectantiviral immunityen_US
dc.subjecthemoglobinen_US
dc.subjectsalmonidsen_US
dc.subjecterythrocytes,en_US
dc.subjectanemiaen_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.titleAntiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytesen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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