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dc.contributor.authorBradbury, Kathryn E.
dc.contributor.authorAppleby, Paul N.
dc.contributor.authorTipper, Sarah J.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorCervenka, Iris
dc.contributor.authorMahamat-Saleh, Yahya
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renée T.
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorStratigos, Alexander J.
dc.contributor.authorPalli, Domenico
dc.contributor.authorGrioni, Sara
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorVeierød, Marit B.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBonet, Catalina
dc.contributor.authorMolina, Elena
dc.contributor.authorHuerta, José M.
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorMerino, Susana
dc.contributor.authorIsaksson, Karolin
dc.contributor.authorStocks, Tanja
dc.contributor.authorLjuslinder, Ingrid
dc.contributor.authorHemmingsson, Oskar
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGunter, Marc J.
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorKey, Timothy J.
dc.date.accessioned2019-05-21T11:45:00Z
dc.date.available2019-05-21T11:45:00Z
dc.date.issued2018-09-07
dc.description.abstractInsulin‐like growth factor‐I (IGF‐I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF‐I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF‐I concentrations and melanoma risk. A nested case–control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF‐I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF‐I concentration and melanoma risk (OR for highest <i>vs</i> lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF‐I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF‐I measured in adulthood and the risk of melanoma.en_US
dc.description.sponsorshipCancer Research UK Cancer Res Associazione Italiana per la Ricerca sul Cancro Bundesministerium für Bildung und Forschung Cancerfonden Centre International de Recherche sur le Cancer Consiglio Nazionale delle Ricerche County Councils of Skane and Vasterbotten Deutsche Krebshilfe Deutsches Krebsforschungszentrum Directorate‐General for Health and Food Safety Dutch Prevention Funds Dutch ZON (Zorg Onderzoek Nederland) Health Research Council of New Zealand Health Research Fund Institut Gustave‐Roussy Institut National de la Santé et de la Recherche Médicale Kræftens Bekæmpelse Kreftforeningen Ligue Contre le Cancer LK Research Funds Medical Research Council Ministerie van Volksgezondheid, Welzijn en Sport Mutuelle Générale de l'Education Nationale Netherlands Cancer Registry NordForsk Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra Statistics Netherland the Hellenic Health Foundation Vetenskapsrådet World Cancer Research Fund Regional Governments of Andalucía, Asturias, Basque Country, Murcia Stat Netherlands (The Netherlands). Institut Gustave Roussy, Mutuelle Générale de l'Education Nationale, Institut National de la Sante et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Res Center (DKFZ), Federal Ministry of Education and Research (BMBF) (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro‐AIRC‐Italy the European Commission Norwegian Cancer Societyen_US
dc.descriptionSource at <a href=https://doi.org/10.1002/ijc.31854>https://doi.org/10.1002/ijc.31854. </a>en_US
dc.identifier.citationBradbury, K.E, Appleby, P.N., Tipper, S.J., Travis, R.C., Allen, N.E., Kvaskoff, M. ... Key, T.J. (2018). Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition. <i>International Journal of Cancer, 144</i>(5), 957-966. https://doi.org/10.1002/ijc.31854en_US
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.otherFRIDAID 1686631
dc.identifier.other10.1002/ijc.31854
dc.identifier.urihttps://hdl.handle.net/10037/15355
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.rights.accessRightsopenAccessen_US
dc.subjectmelanomaen_US
dc.subjectinsulin-like growth factor Ien_US
dc.subjectheighten_US
dc.subjectEPICen_US
dc.subjectbiomarkeren_US
dc.subjectprospective studiesen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleCirculating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutritionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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