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dc.contributor.authorHansen, Tonje Elisabeth
dc.contributor.authorEvjenth, Bjørg
dc.contributor.authorHolt, Jan
dc.date.accessioned2019-05-24T09:23:48Z
dc.date.available2019-05-24T09:23:48Z
dc.date.issued2014-10-08
dc.description.abstract<p><i>Aim: </i>A questionnaire has been used repeatedly in cross-sectional studies to determine the prevalence of asthma, allergic rhinoconjunctivitis (AR) and eczema among schoolchildren in Nordland County, Norway. The current study was designed to validate the questionnaire against clinical assessment as the diagnostic gold standard and to investigate the extent of possible misclassification. <p><i>Methods: </i>A subsample of 801 schoolchildren of 4150, whose parents had answered a questionnaire covering asthma and atopic diseases, underwent a detailed clinical evaluation including a standardized interview, a clinical examination, skin prick tests (SPT), blood samples, spirometry an exercise treadmill test (EIB test) and measurement of exhaled nitrogen oxide (FeNO). <p><i>Results: </i>The questionnaire had a sensitivity of 0.96 and a specificity of 0.87 for the diagnosis of asthma ever compared to clinical assessment. The overall agreement (kappa) was 0.80. After clinical assessment the prevalence of asthma ever was adjusted from 17.6 % to 16.9 % (95% CI: 15.8–18.0). The most sensitive and specific questions in identifying asthmatic children by the questionnaire were questions asking about diagnosis (‘Has the child ever had asthma?’) rather than those covering asthma symptoms such as wheeze, shortness of breath and/or cough. A positive exercise test increased the post-test probability for the asthma diagnosis only to a minimal degree. <p><i>Conclusion: </i>Based on the good agreement between the questionnaire responses and the clinical assessments, it is concluded that the questionnaire had good validity and served as a useful epidemiological tool. Detailed clinical testing added little additional information.en_US
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in the <i>Journal of Asthma</i> on 8 October 2014, available online at <a href=https://doi.org/10.3109/02770903.2014.966914>https://doi.org/10.3109/02770903.2014.966914</a>.en_US
dc.identifier.citationHansen, T.E., Evjenth, B. & Holt, J. (2015). Validation of a questionnaire against clinical assessment in the diagnosis of asthma in school children. <i>Journal of Asthma, 52</i>(3), 262-267. https://doi.org/10.3109/02770903.2014.966914en_US
dc.identifier.cristinIDFRIDAID 1218120
dc.identifier.doi10.3109/02770903.2014.966914
dc.identifier.issn0277-0903
dc.identifier.issn1532-4303
dc.identifier.urihttps://hdl.handle.net/10037/15377
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofHansen, T.E. (2019). The prevalence and possible risk factors of asthma in a subarctic child population. A study of asthma and allergy among schoolchildren i Nordland county. (Doctoral thesis). <a href=https://hdl.handle.net/10037/15313>https://hdl.handle.net/10037/15313</a>
dc.relation.journalJournal of Asthma
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectAtopyen_US
dc.subjectCross-sectionalen_US
dc.subjectEpidemiologyen_US
dc.subjectInstrument validationen_US
dc.subjectReliabilityen_US
dc.titleValidation of a questionnaire against clinical assessment in the diagnosis of asthma in school childrenen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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