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dc.contributor.authorFedirko, Veronika
dc.contributor.authorJenab, Mazda
dc.contributor.authorMéplan, Catherine
dc.contributor.authorJones, Jeb S.
dc.contributor.authorZhu, Wanzhe
dc.contributor.authorSchomburg, Lutz
dc.contributor.authorSiddiq, Afshan
dc.contributor.authorHybsier, Sandra
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOmichessan, Hanane
dc.contributor.authorPerduca, Vittorio
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorMasala, Giovanna
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorBueno-De-Mesquita, Bas
dc.contributor.authorVermeulen, Roel C.H.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorQuirós, Jose Ramón
dc.contributor.authorHuerta, José María
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorGylling, Björn
dc.contributor.authorHarlid, Sophia
dc.contributor.authorBradbury, Kathryn Erica
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGunter, Marc J.
dc.contributor.authorMurphy, Neil
dc.contributor.authorFreisling, Heinz
dc.contributor.authorTsilidis, Kostas
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorHesketh, John E.
dc.contributor.authorHughes, David J.
dc.date.accessioned2019-08-21T13:19:58Z
dc.date.available2019-08-21T13:19:58Z
dc.date.issued2019-04-25
dc.description.abstractSelenoprotein genetic variations and suboptimal selenium (Se) levels may contribute to the risk of colorectal cancer (CRC) development. We examined the association between CRC risk and genotype for single nucleotide polymorphisms (SNPs) in selenoprotein and Se metabolic pathway genes. <i>Illumina Goldengate</i> assays were designed and resulted in the genotyping of 1040 variants in 154 genes from 1420 cases and 1421 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Multivariable logistic regression revealed an association of 144 individual SNPs from 63 Se pathway genes with CRC risk. However, regarding the selenoprotein genes, only <i>TXNRD1</i> rs11111979 retained borderline statistical significance after adjustment for correlated tests (<i>P</i><sub>ACT</sub> = 0.10; <i>P</i><sub>ACT</sub> significance threshold was <i>P</i> < 0.1). SNPs in Wingless/Integrated (Wnt) and Transforming growth factor (TGF) beta-signaling genes (<i>FRZB, SMAD3, SMAD7</i>) from pathways affected by Se intake were also associated with CRC risk after multiple testing adjustments. Interactions with Se status (using existing serum Se and Selenoprotein P data) were tested at the SNP, gene, and pathway levels. Pathway analyses using the modified Adaptive Rank Truncated Product method suggested that genes and gene x Se status interactions in antioxidant, apoptosis, and TGF-beta signaling pathways may be associated with CRC risk. This study suggests that SNPs in the Se pathway alone or in combination with suboptimal Se status may contribute to CRC development.en_US
dc.description.sponsorshipHealth Research Board of Ireland “Europe Against Cancer” Programme of the European Commission (SANCO) Ligue contre le Cancer Institut Gustave Roussy Mutuelle Générale de l’Education Nationale Institut National de la Santé et de la Recherche Médicale (INSERM) German Cancer Aid German Cancer Research Center German Federal Ministry of Education and Research Danish Cancer Society Health Research Fund (FIS) of the Spanish Ministry of Health CIBER en Epidemiología y Salud Pública (CIBERESP), Spain ISCIII RETIC Spanish Regional Governments of Andalusia, Asturias, Basque Country, Murcia Navarra and the Catalan Institute of Oncology Cancer Research UK Medical Research Council, UK Hellenic Health Foundation Italian Association for Research on Cancer Italian National Research Council Compagnia di San Paolo Dutch Ministry of Public Health, Welfare and Sports (VWS) Netherlands Cancer Registry (NKR LK Research Funds Dutch Prevention Funds Dutch ZON (ZorgOnderzoek Nederland) World Cancer Research Fund (WCRF) Statistics Netherlands (The Netherlands) Swedish Cancer Society Swedish Scientific Council Regional Governments of Skane and Vasterbotten, Sweden Nordforsk center of excellence programme HELGA Deutsche Forschungsgemeinschaf Associazione Italiana per la Ricercasul Cancro-AIRC-Italyen_US
dc.descriptionSource at <a href=https://doi.org/10.3390/nu11040935>https://doi.org/10.3390/nu11040935. </a>en_US
dc.identifier.citationFedirko, V., Jenab, M., Méplan, C., Jones, J.S., Zhu, W., Schomburg, L. ... Hughes, D.J. (2019). Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status. <i>Nutrients, 11</i>(4), 935. https://doi.org/10.3390/nu11040935en_US
dc.identifier.issn2072-6643
dc.identifier.otherFRIDAID 1708550
dc.identifier.other10.3390/nu11040935
dc.identifier.urihttps://hdl.handle.net/10037/15989
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalNutrients
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectseleniumen_US
dc.subjectselenium statusen_US
dc.subjectselenoprotein gene variationen_US
dc.subjectselenium pathwayen_US
dc.subjectcolorectal neoplasmsen_US
dc.subjectselenoprotein Pen_US
dc.subjectprospective cohorten_US
dc.subjectcolorectal cancer risken_US
dc.subjectgenetic epidemiology; biomarkersen_US
dc.titleAssociation of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Statusen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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