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dc.contributor.authorBugge, Erlend
dc.contributor.authorWynn, Rolf
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorReitan, Solveig Merete Klæbo
dc.contributor.authorLapid, Maria
dc.contributor.authorGrønli, Ole Kristian
dc.date.accessioned2019-09-11T09:08:38Z
dc.date.available2019-09-11T09:08:38Z
dc.date.issued2019-06-26
dc.description.abstractImmunological abnormalities have been demonstrated in several psychiatric disorders. Predominantly, studies have focused on younger adults, and research on elderly psychiatric in-patients is scant. In this naturalistic study, we investigated changes in cytokine levels during the treatment of diagnostically unselected elderly psychiatric in-patients, and whether these changes could be related to clinical outcomes. Clinical variables, demographic data, lifestyle data, and blood samples, including 27 plasma cytokines representing a broad spectrum of inflammatory mediators, were collected from 81 patients, 60 years and older, at admission and discharge. A subgroup of 49 patients also completed a self-reported clinical, psychiatric status form, indicating their level of recovery during hospitalisation. Statistical analyses demonstrated that a broad range of cytokines fell during treatment, and the fall was associated with clinical improvement, irrespective of psychiatric and somatic diagnoses. Exploiting cytokines as biomarkers of clinical traits might to be of limited use in a general population of elderly psychiatric in-patients as the field stands now.en_US
dc.description.sponsorshipNorthern Norway Regional Health Authorityen_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.psyneuen.2019.06.014>https://doi.org/10.1016/j.psyneuen.2019.06.014. </a>en_US
dc.identifier.citationBugge, E., Wynn, R., Mollnes, T.E., Reitan, S.K., Lapid, M.I. & Grønli, O.K. (2019). Changes in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic study. <i>Psychoneuroendocrinology, 108</i>, 135-139. https://doi.org/10.1016/j.psyneuen.2019.06.014en_US
dc.identifier.issn0306-4530
dc.identifier.issn1873-3360
dc.identifier.otherFRIDAID 1707018
dc.identifier.other10.1016/j.psyneuen.2019.06.014
dc.identifier.urihttps://hdl.handle.net/10037/16157
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPsychoneuroendocrinology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectPsychogeriatricen_US
dc.subjectGerontopsychiatricen_US
dc.subjectCytokineen_US
dc.subjectDepressionen_US
dc.subjectNeuroimmunologyen_US
dc.subjectNeuroinflammationen_US
dc.titleChanges in cytokines during treatment of elderly, hospitalized psychiatric patients - a naturalistic studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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