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dc.contributor.authorHeggdal, Peder Olaf Laugen
dc.contributor.authorAarstad, Hans Jørgen
dc.contributor.authorBrännström, Jonas
dc.contributor.authorVassbotn, Flemming
dc.contributor.authorSpecht, Karsten
dc.date.accessioned2019-11-15T14:19:34Z
dc.date.available2019-11-15T14:19:34Z
dc.date.issued2019-08-06
dc.description.abstract<i>Objective</i>: Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation.<p> <p><i>Design</i>: Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment.<p> <p><i>Study sample</i>: Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls.<p> <p><i>Results</i>: Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus.<p> <p><i>Conclusion</i>: Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.en_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.nicl.2019.101969>https://doi.org/10.1016/j.nicl.2019.101969. </a>en_US
dc.identifier.citationHeggdal, P.O.L., Aarstad, H.J., Brännström, J., Vassbotn, F. & Specht, K. (2019). An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance. <i>NeuroImage: Clinical, 24</i>, 101969. https://doi.org/10.1016/j.nicl.2019.101969en_US
dc.identifier.cristinIDFRIDAID 1739250
dc.identifier.doi10.1016/j.nicl.2019.101969
dc.identifier.issn2213-1582
dc.identifier.urihttps://hdl.handle.net/10037/16674
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalNeuroImage: Clinical
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.subjectVDP::Social science: 200en_US
dc.subjectVDP::Samfunnsvitenskap: 200en_US
dc.titleAn fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominanceen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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