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dc.contributor.authorHelset, E.
dc.contributor.authorSildnes, T.
dc.contributor.authorSeljelid, R.
dc.contributor.authorKonopski, Z. S.
dc.date.accessioned2009-01-07T13:01:13Z
dc.date.available2009-01-07T13:01:13Z
dc.date.issued1993-09-09
dc.description.abstractINCREASED plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-α, IL-1β and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ranged from 0.01 to 1 nM. The maximal response was a 200 to 400% increase in cytokine release. A time-course study revealed that the pattern of cytokines induced by ET-1 was different in monocytes and macrophages, although an early increase in TNF-α was observed in both monocyte and macrophage supernatants. In conclusion, ET-1 stimulates monocytes and macrophages to release cytokines thereby demonstrating a potential role for ET-1 in regulation of inflammatory responses.en
dc.format.extent939604 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationMediators of Inflammation, vol. 2, no. 6, pp. 417-422, 1993. doi:10.1155/S0962935193000596en
dc.identifier.urihttps://hdl.handle.net/10037/1706
dc.identifier.urnURN:NBN:no-uit_munin_1439
dc.language.isoengen
dc.publisherHindawi Publishing Corporationen
dc.rights.accessRightsopenAccess
dc.subjectCytokinesen
dc.subjectEndothelin-1en
dc.subjectIL-1βen
dc.subjectIL-6en
dc.subjectInflammationen
dc.subjectMacrophagesen
dc.subjectMonocytesen
dc.subjectTNF-αen
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en
dc.titleEndothelin-1 stimulates human monocytes in vitro to release TNF-α, IL-1β and IL-6en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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