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dc.contributor.authorVrieling, Alina
dc.contributor.authorBueno-de-Mesquita, Hendrik Bastiaan
dc.contributor.authorRos, Martine M.
dc.contributor.authorKampman, Ellen
dc.contributor.authorAben, Katja K.
dc.contributor.authorBüchner, Frederike L.
dc.contributor.authorJansen, Eugène H.
dc.contributor.authorRoswall, Nina
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Chiristine
dc.contributor.authorCadeau, Claire
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorWeikert, Steffen
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorSieri, Sabina
dc.contributor.authorPalli, Domenico
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorJakszyn, Paula
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSánchez, María-José
dc.contributor.authorEhrnström, Roy
dc.contributor.authorMalm, Johan
dc.contributor.authorLjungberg, Börje
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick J.
dc.contributor.authorBrennan, Paul
dc.contributor.authorJohansson, Mattias
dc.contributor.authorRiboli, Elio
dc.contributor.authorKiemeney, Lambertus A.
dc.date.accessioned2020-01-13T08:55:48Z
dc.date.available2020-01-13T08:55:48Z
dc.date.issued2019-01-29
dc.description.abstractPublished associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case–control analysis within the European Prospective Investigation into Cancer and Nutrition (EPIC) investigated associations between pre‐diagnostic serum folate, homocysteine, vitamins B6 and B12 and the risk of urothelial cell carcinomas of the bladder (UCC). A total of 824 patients with newly diagnosed UCC were matched with 824 cohort members. Serum folate, homocysteine, and vitamins B6 and B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) for total, aggressive, and non‐aggressive UCC were estimated using conditional logistic regression with adjustment for smoking status, smoking duration and intensity, and other potential confounders. Additionally, statistical interaction with smoking status was assessed. A halving in serum folate concentrations was moderately associated with risk of UCC (OR: 1.18; 95% CI: 0.98–1.43), in particular aggressive UCC (OR: 1.34; 95% CI: 1.02–1.75; <i>p</i>‐heterogeneity = 0.19). Compared to never smokers in the highest quartile of folate concentrations, this association seemed only apparent among current smokers in the lowest quartile of folate concentrations (OR: 6.26; 95% CI: 3.62–10.81, <i>p</i>‐interaction = 0.07). Dietary folate was not associated with aggressive UCC (OR: 1.26; 95% CI: 0.81–1.95; <i>p</i>‐heterogeneity = 0.14). No association was observed between serum homocysteine, vitamins B6 and B12 and risk of UCC. This study suggests that lower serum folate concentrations are associated with increased UCC risk, in particular aggressive UCC. Residual confounding by smoking cannot be ruled out and these findings require confirmation in future studies with multiple measurements.en_US
dc.identifier.citationVrieling A, Bueno-de-Mesquita HB, Ros MM, Kampman E, Aben KK, Büchner FL, Jansen, Roswall N, Tjønneland A, Boutron-Ruault M, Cadeau C, Chang-Claude J, Kaaks R, Weikert S, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Sieri S, Palli D, Panico S, Peeters PH, Weiderpass E, Skeie G, Jakszyn P, Chirlaque M, Ardanaz E, Sánchez M, Ehrnström R, Malm J, Ljungberg B, Khaw K, Wareham NJ, Brennan P, Johansson M, Riboli E, Kiemeney LA. One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition. International Journal of Cancer. 2019en_US
dc.identifier.cristinIDFRIDAID 1703986
dc.identifier.doi10.1002/ijc.32165
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/17071
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/?/?/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleOne-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutritionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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