| dc.contributor.author | Robertsen, Børre | |
| dc.contributor.author | Greiner-Tollersrud, Linn | |
| dc.contributor.author | Jørgensen, Lars Gaute | |
| dc.date.accessioned | 2020-01-31T12:15:47Z | |
| dc.date.available | 2020-01-31T12:15:47Z | |
| dc.date.issued | 2018-09-06 | |
| dc.description.abstract | Mx proteins are antiviral GTPases, which are induced by type I IFN and virus infection. Analysis of the Atlantic salmon genome revealed the presence of 9 Mx genes localized to three chromosomes. A cluster of three Mx genes (SsaMx1 – SsaMx3), which includes previously cloned Mx genes, is present on chromosome (Chr) 12. A cluster of five Mx genes (SsaMx4-SsaMx8) is present on Chr25 while one Mx gene (SsaMx9) is present on Chr9. Phylogenetic and gene synteny analyses showed that SsaMx1-SsaMx3 are most closely related to the main group of teleost Mx proteins. In contrast, SsaMx 4-SsaMx9 formed a separate group together with zebrafish MxD and MxG and eel MxB. The Mx cluster in Chr25 showed gene synteny similar to a Mx gene cluster in the gar genome. Expression of Mx genes in cell lines stimulated with recombinant IFNs showed that Mx genes in Chr12 responded more strongly to type I IFN than to type II IFN (IFN gamma) whilst Mx genes in Chr25 responded more strongly to IFN gamma than to type I IFNs. SsaMx9 showed no response to the IFNs. | en_US |
| dc.description | Accepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a> | en_US |
| dc.identifier.citation | Robertsen B, Greiner-Tollersrud L, Jørgensen LG. Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN. Developmental and Comparative Immunology. 2019;90:80-89 | en_US |
| dc.identifier.cristinID | FRIDAID 1696604 | |
| dc.identifier.doi | 10.1016/j.dci.2018.09.004 | |
| dc.identifier.issn | 0145-305X | |
| dc.identifier.issn | 1879-0089 | |
| dc.identifier.uri | https://hdl.handle.net/10037/17285 | |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.journal | Developmental and Comparative Immunology | |
| dc.rights.accessRights | openAccess | en_US |
| dc.rights.holder | © 2018 Elsevier Ltd. All rights reserved. | en_US |
| dc.subject | VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920 | en_US |
| dc.subject | VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920 | en_US |
| dc.title | Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN | en_US |
| dc.type.version | acceptedVersion | en_US |
| dc.type | Journal article | en_US |
| dc.type | Tidsskriftartikkel | en_US |
| dc.type | Peer reviewed | en_US |
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