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dc.contributor.authorJalilian, Hamed
dc.contributor.authorZiaei, Mansour
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorRueegg, Corina Silvia
dc.contributor.authorKhosravi, Yahya
dc.contributor.authorKjærheim, Kristina
dc.date.accessioned2020-02-04T08:22:10Z
dc.date.available2020-02-04T08:22:10Z
dc.date.issued2019-02-08
dc.description.abstractFirefighters are exposed to both known and suspected carcinogens. This study aims to systematically review the literature on the association of firefighting occupation and cancer incidence and mortality, overall and for specific cancer sites. A systematic review using PubMed, Embase, and Web of Science was performed up to January 1, 2018. We extracted risk estimates of cancers and calculated summary incidence risk estimates (SIRE), summary mortality risk estimates (SMRE), and their 95% confidence intervals (CI). Publication bias and risk of bias in individual studies were assessed using Begg's and Egger's tests and the Newcastle‐Ottawa scale (NOS), respectively. We included 50 papers in the review and 48 in the meta‐analysis. We found significantly elevated SIREs for cancer of the colon (1.14; CI 1.06 to 1.21), rectum (1.09; CI 1.00 to 1.20), prostate (1.15; CI 1.05 to 1.27), testis (1.34; CI 1.08 to 1.68), bladder (1.12; CI 1.04 to 1.21), thyroid (1.22; CI 1.01 to 1.48), pleura (1.60; CI 1.09 to 2.34), and for malignant melanoma (1.21; CI 1.02 to 1.45). We found significant SMREs of 1.36 (1.18 to 1.57) and 1.42 (1.05 to 1.90) for rectal cancer and Non‐Hodgkin's lymphoma, respectively. Considering the significantly elevated risk of some cancers in this occupational group, we suggest improving preventive measures and securing adequate and relevant medical attention for this group. Further studies with more accurate and in‐depth exposure assessments are indicated.en_US
dc.descriptionThis is the peer reviewed version of the following article: Jalilian, H., Ziaei, M., Weiderpass, E., Rueegg, C. S., Khosravi, Y. & Kjærheim, K. (2019). Cancer incidence and mortality among firefighters. <i>International Journal of Cancer, 145</i>(10), 2639-2646., which has been published in final form at <a href=https://doi.org/10.1002/ijc.32199>https://doi.org/10.1002/ijc.32199</a . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationJalilian, Ziaei, Weiderpass E, Rueegg CS, Khosravi, Kjærheim KJ. Cancer incidence and mortality among firefighters. International Journal of Cancer. 2019en_US
dc.identifier.cristinIDFRIDAID 1703946
dc.identifier.doi10.1002/ijc.32199
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttps://hdl.handle.net/10037/17313
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalInternational Journal of Cancer
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-PEOPLE/609020/EU/SCIENTIA-FELLOWS: International Postdoctoral Fellowship Programme/SCIENTIA-FELLOWS/
dc.rights.accessRightsopenAccessen_US
dc.rights.holder©2019 UICCen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleCancer incidence and mortality among firefightersen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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